COTL1 (coactosin like F-actin binding protein 1)

2007-02-01  

Identity

HGNC
COTL1
LOCATION
16q24.1
LOCUSID
23406
ALIAS
CLP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23406
MIM: 606748
HGNC: 18304
Ensembl: ENSG00000103187

Variants:

dbSNP: 23406
ClinVar: 23406
TCGA: ENSG00000103187
COSMIC: COTL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103187ENST00000262428Q14019
ENSG00000103187ENST00000262428A0A384MTY2
ENSG00000103187ENST00000564057H3BT58
ENSG00000103187ENST00000567786A0A087WWC7

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
289253972018Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling.11
289253972018Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling.11
278934172017Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression.31
278934172017Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression.31
244547962014Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse.26
250342522014Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis.20
244547962014Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse.26
250342522014Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis.20
223736592012Differential expression of PAI-RBP1, C1orf142, and COTL1 in non-small cell lung cancer cell lines with different tumor metastatic potential.11
223736592012Differential expression of PAI-RBP1, C1orf142, and COTL1 in non-small cell lung cancer cell lines with different tumor metastatic potential.11
210470532011Proteomic analysis of human small cell lung cancer tissues: up-regulation of coactosin-like protein-1.18
210470532011Proteomic analysis of human small cell lung cancer tissues: up-regulation of coactosin-like protein-1.18
193077562009Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders.11
193077562009Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders.11
198076932009Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.20

Citation

Dessen P

COTL1 (coactosin like F-actin binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46173/css/meetings/