PLA2G4C (phospholipase A2 group IVC)

2007-02-01 Affiliation

Identity

HGNC

PLA2G4C

LOCATION

19q13.33

LOCUSID

8605

ALIAS

CPLA2-gamma

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8605
MIM: 603602
HGNC: 9037
Ensembl: ENSG00000105499

Variants:

dbSNP: 8605
ClinVar: 8605
TCGA: ENSG00000105499
COSMIC: PLA2G4C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000105499	ENST00000354276	Q9UP65
ENSG00000105499	ENST00000595161	M0QY18
ENSG00000105499	ENST00000595487	M0R0M8
ENSG00000105499	ENST00000596138	M0R0F6
ENSG00000105499	ENST00000596352	M0R1B4
ENSG00000105499	ENST00000597713	M0R3I9
ENSG00000105499	ENST00000598488	M0QX83
ENSG00000105499	ENST00000599111	Q9UP65
ENSG00000105499	ENST00000599300	M0QZB1
ENSG00000105499	ENST00000599921	Q9UP65
ENSG00000105499	ENST00000599921	A0A024QZH0
ENSG00000105499	ENST00000601946	M0R339

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerophospholipid metabolism	KEGG	ko00564
Ether lipid metabolism	KEGG	ko00565
Arachidonic acid metabolism	KEGG	ko00590
Linoleic acid metabolism	KEGG	ko00591
alpha-Linolenic acid metabolism	KEGG	ko00592
MAPK signaling pathway	KEGG	ko04010
VEGF signaling pathway	KEGG	ko04370
Fc epsilon RI signaling pathway	KEGG	ko04664
Long-term depression	KEGG	ko04730
GnRH signaling pathway	KEGG	ko04912
Glycerophospholipid metabolism	KEGG	hsa00564
Ether lipid metabolism	KEGG	hsa00565
Arachidonic acid metabolism	KEGG	hsa00590
Linoleic acid metabolism	KEGG	hsa00591
alpha-Linolenic acid metabolism	KEGG	hsa00592
MAPK signaling pathway	KEGG	hsa04010
VEGF signaling pathway	KEGG	hsa04370
Fc epsilon RI signaling pathway	KEGG	hsa04664
Long-term depression	KEGG	hsa04730
GnRH signaling pathway	KEGG	hsa04912
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Metabolic pathways	KEGG	hsa01100
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Serotonergic synapse	KEGG	hsa04726
Ovarian steroidogenesis	KEGG	hsa04913
Ovarian steroidogenesis	KEGG	ko04913
Ras signaling pathway	KEGG	hsa04014
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Platelet activation	KEGG	hsa04611
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
Glycerophospholipid biosynthesis	REACTOME	R-HSA-1483206
Acyl chain remodelling of PE	REACTOME	R-HSA-1482839
Hydrolysis of LPE	REACTOME	R-HSA-1483152
Acyl chain remodelling of PC	REACTOME	R-HSA-1482788
Hydrolysis of LPC	REACTOME	R-HSA-1483115
Acyl chain remodelling of PI	REACTOME	R-HSA-1482922
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37290257	2023	Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients.	0
37290257	2023	Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients.	0
28651698	2017	An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population.	3
28651698	2017	An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population.	3
26364726	2016	Prognostic significance of PLA2G4C gene polymorphism in patients with stage II colorectal cancer.	3
27611910	2016	The rs251684 Variant of PLA2G4C Is Associated with Autism Spectrum Disorder in the Northeast Han Chinese Population.	2
26364726	2016	Prognostic significance of PLA2G4C gene polymorphism in patients with stage II colorectal cancer.	3
27611910	2016	The rs251684 Variant of PLA2G4C Is Associated with Autism Spectrum Disorder in the Northeast Han Chinese Population.	2
26160611	2015	Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients.	2
26160611	2015	Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients.	2
22878031	2012	The DNA methylation profile of PLA2G4C gene promoter in schizophrenia.	4
22878031	2012	The DNA methylation profile of PLA2G4C gene promoter in schizophrenia.	4
21600875	2011	Downregulation of cPLA2γ expression inhibits EGF-induced chemotaxis of human breast cancer cells through Akt pathway.	4
22108055	2011	Regulation of macrophage differentiation and polarization by group IVC phospholipase A₂.	5
21600875	2011	Downregulation of cPLA2γ expression inhibits EGF-induced chemotaxis of human breast cancer cells through Akt pathway.	4

Citation

Dessen P

PLA2G4C (phospholipase A2 group IVC)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46175/css/gene-explorer/case-report-explorer/