ADIPOQ (adiponectin, C1Q and collagen domain containing)

2007-02-01 Affiliation

Identity

HGNC

ADIPOQ

LOCATION

3q27.3

LOCUSID

9370

ALIAS

ACDC,ACRP30,ADIPQTL1,ADPN,APM-1,APM1,GBP28

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9370
MIM: 605441
HGNC: 13633
Ensembl: ENSG00000181092

Variants:

dbSNP: 9370
ClinVar: 9370
TCGA: ENSG00000181092
COSMIC: ADIPOQ

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000181092	ENST00000320741	Q15848
ENSG00000181092	ENST00000320741	A8K660
ENSG00000181092	ENST00000444204	Q15848
ENSG00000181092	ENST00000444204	A8K660

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
PPAR signaling pathway	KEGG	ko03320
Adipocytokine signaling pathway	KEGG	ko04920
Type II diabetes mellitus	KEGG	ko04930
PPAR signaling pathway	KEGG	hsa03320
Adipocytokine signaling pathway	KEGG	hsa04920
Type II diabetes mellitus	KEGG	hsa04930
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
AMPK inhibits chREBP transcriptional activation activity	REACTOME	R-HSA-163680
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	REACTOME	R-HSA-381340
Longevity regulating pathway	KEGG	hsa04211

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128406954	Weight gain	Disease	VariantAnnotation	not associated		24953421
PA166123368	schizoaffective disorder	Disease	VariantAnnotation	not associated		24953421
PA443886	Diabetes Mellitus	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD
PA447216	Schizophrenia	Disease	VariantAnnotation	not associated		24953421
PA450970	pioglitazone	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD
PA452233	antipsychotics	Chemical	VariantAnnotation	not associated		24953421

References

Pubmed ID	Year	Title	Citations
37351836	2024	Lower adiponectin is associated with higher anthropometry and insulin resistance but not with low cardiorespiratory fitness in adolescents.	0
37831337	2024	Adiponectin rs1501299 and chemerin rs17173608 gene polymorphism in children with type 1 diabetes mellitus: relation with macroangiopathy and peripheral artery disease.	0
37855224	2024	The role of adiposity, adipokines and polymorphisms of leptin and adiponectin in myelodysplastic syndromes.	0
37859345	2024	A cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin.	2
37897683	2024	Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large-scale observational and Mendelian randomization evidence.	2
37923928	2024	Visceral adipose tissue adiponectin predicts excess weight loss after bariatric surgery in females with severe obesity.	2
37939678	2024	Correlation of Plasma Adiponectin Levels and Adiponectin Gene Polymorphisms with Idiopathic Atrial Fibrillation.	1
37985302	2024	Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients.	0
38031795	2024	Potential Association of The Pathogenic Kruppel-like Factor 14 (KLF14) and Adiponectin (ADIPOQ) SNVs with Susceptibility to T2DM.	0
38134479	2024	Adiponectin-mediated regulation of the adiponectin cascade in cardiovascular disease: Updates.	1
38280832	2024	The role of adiponectin in Alzheimer's disease: A translational review.	0
38396693	2024	Preliminary Report on the Influence of Acute Inflammation on Adiponectin Levels in Older Inpatients with Different Nutritional Status.	1
38438104	2024	The effect of plasma cytokines on the expression of adiponectin and its receptors in the synovial membrane of joints and the infrapatellar fat pad in patients with rheumatoid arthritis and osteoarthritis.	1
38489870	2024	Association of adiponectin and its receptor gene polymorphisms with the risk of coronary heart disease in northern Guangxi.	0
38492235	2024	Adiponectin Inhibits the Progression of Obesity-Associated Papillary Thyroid Carcinoma Through Autophagy.	1

Citation

Dessen P

ADIPOQ (adiponectin, C1Q and collagen domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46188/meetings/gene-explorer/js/gene-fusions-explorer/