KHK (ketohexokinase)

2007-02-01  

Identity

HGNC
KHK
LOCATION
2p23.3
LOCUSID
3795
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3795
MIM: 614058
HGNC: 6315
Ensembl: ENSG00000138030

Variants:

dbSNP: 3795
ClinVar: 3795
TCGA: ENSG00000138030
COSMIC: KHK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138030ENST00000260598P50053
ENSG00000138030ENST00000260599P50053
ENSG00000138030ENST00000260599A0A140VJM6
ENSG00000138030ENST00000429697C9JDL1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fructose and mannose metabolismKEGGko00051
Fructose and mannose metabolismKEGGhsa00051
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Fructose metabolismREACTOMER-HSA-5652084
Fructose catabolismREACTOMER-HSA-70350

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449716fructoseChemicalPathwayassociated24915143

References

Pubmed IDYearTitleCitations
372302142023Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.2
372302142023Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.2
351336292022USP36 promotes tumor growth of non-small cell lung cancer via increasing KHK-A expression by regulating c-MYC-hnRNPH1/H2 axis.6
352578332022GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer.12
351336292022USP36 promotes tumor growth of non-small cell lung cancer via increasing KHK-A expression by regulating c-MYC-hnRNPH1/H2 axis.6
352578332022GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer.12
329287082021KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1.3
336212672021Prevalence and cardiometabolic correlates of ketohexokinase gene variants among UK Biobank participants.2
329287082021KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1.3
336212672021Prevalence and cardiometabolic correlates of ketohexokinase gene variants among UK Biobank participants.2
331161232020Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer.32
331161232020Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer.32
310324102019The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62.33
310324102019The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62.33
289547332017Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers.59

Citation

Dessen P

KHK (ketohexokinase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46273/js/hgnc