UGT1A10 (UDP glucuronosyltransferase family 1 member A10)

2007-02-01  

Identity

HGNC
UGT1A10
LOCATION
2q37.1
LOCUSID
54575
ALIAS
GNT1,UDPGT,UGT-1A,UGT-1J,UGT1,UGT1-01,UGT1-10,UGT1.1,UGT1.10,UGT1A,UGT1A1,UGT1J,hUG-BR1

Other Information

Locus ID:

NCBI: 54575
MIM: 606435
HGNC: 12531
Ensembl: ENSG00000242515

Variants:

dbSNP: 54575
ClinVar: 54575
TCGA: ENSG00000242515
COSMIC: UGT1A10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000242515ENST00000344644Q9HAW8
ENSG00000242515ENST00000344644Q5DT02
ENSG00000242515ENST00000373445Q9HAW8

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Ascorbate and aldarate metabolismKEGGko00053
Steroid hormone biosynthesisKEGGko00140
Retinol metabolismKEGGko00830
Porphyrin and chlorophyll metabolismKEGGko00860
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Drug metabolism - other enzymesKEGGko00983
Pentose and glucuronate interconversionsKEGGhsa00040
Ascorbate and aldarate metabolismKEGGhsa00053
Steroid hormone biosynthesisKEGGhsa00140
Retinol metabolismKEGGhsa00830
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Glucuronate pathway (uronate pathway)KEGGM00014
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Glucuronate pathway (uronate pathway)KEGGhsa_M00014

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748728mycophenolic acidChemicalPathwayassociated24220207
PA165110775SN-38ChemicalPathwayassociated
PA165958521febuxostatChemicalClinicalAnnotationassociatedPD27798726
PA420UGT1A1GeneVipGeneassociated15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPKPD15761113, 21806385, 27900402, 28763744
PA444318GoutDiseaseClinicalAnnotationassociatedPD27798726
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPK29791011
PA445629SeizuresDiseaseClinicalAnnotationassociatedPD27900402
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD
PA448320allopurinolChemicalClinicalAnnotationassociatedPD27798726
PA450428methotrexateChemicalClinicalAnnotationassociatedPK29791011
PA450732oxcarbazepineChemicalClinicalAnnotationassociatedPD27900402
PA451257risperidoneChemicalClinicalAnnotationassociatedPD
PA451846valproic acidChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD15761113, 21806385, 28763744

References

Pubmed IDYearTitleCitations
295198532018Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.1
295198532018Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.1
255476282015Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.13
262201432015Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.5
255476282015Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.13
262201432015Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.5
242398972014Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10.11
252649622014Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage.2
242398972014Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10.11
252649622014Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage.2
231608182013Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.7
231608182013Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.7
220316232012Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.4
226590922012Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.6
220316232012Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.4

Citation

Dessen P

UGT1A10 (UDP glucuronosyltransferase family 1 member A10)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46276/css/deep-insight-explorer/