LHX6 (LIM homeobox 6)

2007-02-01  

Identity

HGNC
LHX6
LOCATION
9q33.2
LOCUSID
26468
ALIAS
LHX6.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26468
MIM: 608215
HGNC: 21735
Ensembl: ENSG00000106852

Variants:

dbSNP: 26468
ClinVar: 26468
TCGA: ENSG00000106852
COSMIC: LHX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106852ENST00000340587Q9UPM6
ENSG00000106852ENST00000373754Q9UPM6
ENSG00000106852ENST00000373755Q9UPM6
ENSG00000106852ENST00000373755A0A024R852
ENSG00000106852ENST00000394319Q9UPM6
ENSG00000106852ENST00000464484H0YKH7
ENSG00000106852ENST00000482062H0YMY8
ENSG00000106852ENST00000541397Q9UPM6
ENSG00000106852ENST00000559895Q9UPM6
ENSG00000106852ENST00000560485H0YMH3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361549492023LHX6 promoter hypermethylation in oncological pediatric patients conceived by IVF.1
361549492023LHX6 promoter hypermethylation in oncological pediatric patients conceived by IVF.1
347734432022Tumor suppressor LHX6 upregulation contributes to the inhibitory effect of miR-346 knockdown on colorectal cancer cell growth.1
353843552022The exon 12-containing LHX6 isoforms promote cervical cancer cell proliferation by regulating the MAPK signaling pathway.2
347734432022Tumor suppressor LHX6 upregulation contributes to the inhibitory effect of miR-346 knockdown on colorectal cancer cell growth.1
353843552022The exon 12-containing LHX6 isoforms promote cervical cancer cell proliferation by regulating the MAPK signaling pathway.2
319077932020LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons.8
322489802020Methylation-mediated silencing of the LIM homeobox 6 (LHX6) gene promotes cell proliferation in human pancreatic cancer.4
319077932020LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons.8
322489802020Methylation-mediated silencing of the LIM homeobox 6 (LHX6) gene promotes cell proliferation in human pancreatic cancer.4
311510602019Epigenetic inactivation of LHX6 mediated microcystin-LR induced hepatocarcinogenesis via the Wnt/β-catenin and P53 signaling pathways.8
311510602019Epigenetic inactivation of LHX6 mediated microcystin-LR induced hepatocarcinogenesis via the Wnt/β-catenin and P53 signaling pathways.8
292263222018MiR-1290 promotes proliferation, migration, and invasion of glioma cells by targeting LHX6.22
295339042018Downregulation of tumor-suppressor gene LHX6 in cancer: a systematic review.3
302519532018Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6.19

Citation

Dessen P

LHX6 (LIM homeobox 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46414/case-report-explorer/deep-insight-explorer/