RBM17 (RNA binding motif protein 17)

2007-02-01  

Identity

HGNC
RBM17
LOCATION
10p15.1
LOCUSID
84991
ALIAS
SPF45
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84991
MIM: 606935
HGNC: 16944
Ensembl: ENSG00000134453

Variants:

dbSNP: 84991
ClinVar: 84991
TCGA: ENSG00000134453
COSMIC: RBM17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134453ENST00000379888Q96I25
ENSG00000134453ENST00000379888Q5W009
ENSG00000134453ENST00000418631Q5W011
ENSG00000134453ENST00000432931Q5W010
ENSG00000134453ENST00000437845Q5W012
ENSG00000134453ENST00000446108Q96I25
ENSG00000134453ENST00000446108Q5W009
ENSG00000134453ENST00000447032H0Y6J6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365200542023AKT1 phosphorylates RBM17 to promote Sox2 transcription by modulating alternative splicing of FOXM1 to enhance cancer stem cell properties in colorectal cancer cells.4
380650982023SAP30BP interacts with RBM17/SPF45 to promote splicing in a subset of human short introns.0
365200542023AKT1 phosphorylates RBM17 to promote Sox2 transcription by modulating alternative splicing of FOXM1 to enhance cancer stem cell properties in colorectal cancer cells.4
380650982023SAP30BP interacts with RBM17/SPF45 to promote splicing in a subset of human short introns.0
357815332022The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors.3
357815332022The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors.3
342257732021A 5'-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer.27
343897062021SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns.8
342257732021A 5'-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer.27
343897062021SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns.8
324970932020Exploration of the effects of the CYCLOPS gene RBM17 in hepatocellular carcinoma.3
324970932020Exploration of the effects of the CYCLOPS gene RBM17 in hepatocellular carcinoma.3
310028162019Hypoxia alters splicing of the cancer associated Fas gene.10
310028162019Hypoxia alters splicing of the cancer associated Fas gene.10
302279402018RBM17 controls apoptosis and proliferation to promote Glioma progression.10

Citation

Dessen P

RBM17 (RNA binding motif protein 17)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46514/teaching-explorer/haematological-explorer/gene-fusions/?id=46514