IRF3 (interferon regulatory factor 3)

2007-02-01  

Identity

HGNC
IRF3
LOCATION
19q13.33
LOCUSID
3661
ALIAS
IIAE7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3661
MIM: 603734
HGNC: 6118
Ensembl: ENSG00000126456

Variants:

dbSNP: 3661
ClinVar: 3661
TCGA: ENSG00000126456
COSMIC: IRF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126456ENST00000309877Q14653
ENSG00000126456ENST00000377135M0QYT9
ENSG00000126456ENST00000377139Q14653
ENSG00000126456ENST00000442265Q14653
ENSG00000126456ENST00000593337M0R3E9
ENSG00000126456ENST00000593818M0R0X9
ENSG00000126456ENST00000593922M0QYT9
ENSG00000126456ENST00000595034M0QXC8
ENSG00000126456ENST00000596756M0R3C2
ENSG00000126456ENST00000596765Q14653
ENSG00000126456ENST00000596788M0R3H7
ENSG00000126456ENST00000596822M0QX56
ENSG00000126456ENST00000597198Q14653
ENSG00000126456ENST00000597636M0QZB8
ENSG00000126456ENST00000598108M0R205
ENSG00000126456ENST00000598808M0QYT9
ENSG00000126456ENST00000599144M0QYT9
ENSG00000126456ENST00000599223Q14653
ENSG00000126456ENST00000600022Q14653
ENSG00000126456ENST00000600453M0R007
ENSG00000126456ENST00000600911M0QZB7
ENSG00000126456ENST00000601291Q14653
ENSG00000126456ENST00000601373M0R0R8
ENSG00000126456ENST00000601809M0QYX3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
PertussisKEGGko05133
PertussisKEGGhsa05133
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hepatitis BKEGGhsa05161
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonREACTOMER-HSA-936964
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF3-dependent IRF activation pathwayREACTOMER-HSA-918233
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
ZBP1(DAI) mediated induction of type I IFNsREACTOMER-HSA-1606322
IRF3 mediated activation of type 1 IFNREACTOMER-HSA-1606341
STING mediated induction of host immune responsesREACTOMER-HSA-1834941
IRF3-mediated induction of type I IFNREACTOMER-HSA-3270619
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN productionREACTOMER-HSA-3134973
Regulation of innate immune responses to cytosolic DNAREACTOMER-HSA-3134975
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Interferon gamma signalingREACTOMER-HSA-877300
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164722208MAVSGenePathwayassociated26111151

References

Pubmed IDYearTitleCitations
377257542024Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1.6
382338532024Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation.1
383169912024Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer.1
383754702024IRF3 function and immunological gaps in sepsis.1
383967752024The African Swine Fever Virus Virulence Determinant DP96R Suppresses Type I IFN Production Targeting IRF3.0
385561052024Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.0
386632542024Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.0
377257542024Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1.6
382338532024Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation.1
383169912024Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer.1
383754702024IRF3 function and immunological gaps in sepsis.1
383967752024The African Swine Fever Virus Virulence Determinant DP96R Suppresses Type I IFN Production Targeting IRF3.0
385561052024Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.0
386632542024Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.0
368613862023Pellino3 ligase negatively regulates influenza B dependent RIG-I signalling through downregulation of TRAF3-mediated induction of the transcription factor IRF3 and IFNβ production.1

Citation

Dessen P

IRF3 (interferon regulatory factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46567/cancer-prone-explorer/js/tumors-explorer/