AURKAIP1 (aurora kinase A interacting protein 1)

2007-03-01  

Identity

HGNC
AURKAIP1
LOCATION
1p36.33
LOCUSID
54998
ALIAS
AIP,AKIP,MRP-S38
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54998
MIM: 609183
HGNC: 24114
Ensembl: ENSG00000175756

Variants:

dbSNP: 54998
ClinVar: 54998
TCGA: ENSG00000175756
COSMIC: AURKAIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175756ENST00000321751Q9NWT8
ENSG00000175756ENST00000321751A0A024R0F0
ENSG00000175756ENST00000338338Q9NWT8
ENSG00000175756ENST00000338338A0A024R0F0
ENSG00000175756ENST00000338370Q9NWT8
ENSG00000175756ENST00000338370A0A024R0F0
ENSG00000175756ENST00000378853Q9NWT8
ENSG00000175756ENST00000378853A0A024R0F0

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial translationREACTOMER-HSA-5368287
Mitochondrial translation initiationREACTOMER-HSA-5368286
Mitochondrial translation elongationREACTOMER-HSA-5389840
Mitochondrial translation terminationREACTOMER-HSA-5419276

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380406912023AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer.0
380406912023AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer.0
223568262012Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.48
223568262012Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.48
219329832011Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein.16
219329832011Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein.16
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
192215042009The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents.34
192215042009The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents.34
183919812008AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.11
185216202008Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.74
183919812008AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.11
185216202008Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.74
174529722007Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A.43

Citation

Dessen P

AURKAIP1 (aurora kinase A interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-03-01

Online version: http://atlasgeneticsoncology.org/gene/46620/teaching-explorer/tumors-explorer/deep-insight-explorer/