APOBEC3G (apolipoprotein B mRNA editing enzyme catalytic subunit 3G)

2007-03-01  

Identity

HGNC
APOBEC3G
LOCATION
22q13.1
LOCUSID
60489
ALIAS
A3G,ARCD,ARP-9,ARP9,CEM-15,CEM15,MDS019,bK150C2.7,dJ494G10.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 60489
MIM: 607113
HGNC: 17357
Ensembl: ENSG00000239713

Variants:

dbSNP: 60489
ClinVar: 60489
TCGA: ENSG00000239713
COSMIC: APOBEC3G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000239713ENST00000407997Q9HC16

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
APOBEC3G mediated resistance to HIV-1 infectionREACTOMER-HSA-180689
Vif-mediated degradation of APOBEC3GREACTOMER-HSA-180585

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380728792024HIV-1 Vif protein sequence variations in South African people living with HIV and their influence on Vif-APOBEC3G interaction.1
388654052024Prevalence of HBsAg among Moroccan HIV-1 infected patients and APOBEC3G variant frequencies in HIV-1/HBV co-infection.0
380728792024HIV-1 Vif protein sequence variations in South African people living with HIV and their influence on Vif-APOBEC3G interaction.1
388654052024Prevalence of HBsAg among Moroccan HIV-1 infected patients and APOBEC3G variant frequencies in HIV-1/HBV co-infection.0
363256812023APOBEC3G protects the genome of human cultured cells and mice from radiation-induced damage.1
364801862023The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer.11
365989812023Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase.10
367540862023The structural basis for HIV-1 Vif antagonism of human APOBEC3G.19
369281172023Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-κ activation and APOBEC3G induction.4
380691172023APOBEC3G Is a p53-Dependent Restriction Factor in Respiratory Syncytial Virus Infection of Human Cells Included in the p53/Immune Axis.0
381052912023Regulatory variants of APOBEC3 genes potentially associate with COVID-19 severity in populations with African ancestry.0
363256812023APOBEC3G protects the genome of human cultured cells and mice from radiation-induced damage.1
364801862023The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer.11
365989812023Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase.10
367540862023The structural basis for HIV-1 Vif antagonism of human APOBEC3G.19

Citation

Dessen P

APOBEC3G (apolipoprotein B mRNA editing enzyme catalytic subunit 3G)

Atlas Genet Cytogenet Oncol Haematol. 2007-03-01

Online version: http://atlasgeneticsoncology.org/gene/46621/css/lib/haematological-explorer/cancer-prone-explorer/