GSPT2 (G1 to S phase transition 2)

2007-04-01  

Identity

HGNC
LOCATION
Xp11.22
LOCUSID
ALIAS
ERF3B,GST2
FUSION GENES

Other Information

Locus ID:

NCBI: 23708
MIM: 300418
HGNC: 4622
Ensembl: ENSG00000189369

Variants:

dbSNP: 23708
ClinVar: 23708
TCGA: ENSG00000189369
COSMIC: GSPT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189369ENST00000340438Q8IYD1

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation TerminationREACTOMER-HSA-72764
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
302722522018eRF3b-37 inhibits the TGF-β1-induced activation of hepatic stellate cells by regulating cell proliferation, G0/G1 arrest, apoptosis and migration.2
302722522018eRF3b-37 inhibits the TGF-β1-induced activation of hepatic stellate cells by regulating cell proliferation, G0/G1 arrest, apoptosis and migration.2
284147752017Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability.7
284147752017Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability.7
244660592014eRF3b, a biomarker for hepatocellular carcinoma, influences cell cycle and phosphoralation status of 4E-BP1.8
245690732014The processed isoform of the translation termination factor eRF3 localizes to the nucleus to interact with the ARF tumor suppressor.3
244660592014eRF3b, a biomarker for hepatocellular carcinoma, influences cell cycle and phosphoralation status of 4E-BP1.8
245690732014The processed isoform of the translation termination factor eRF3 localizes to the nucleus to interact with the ARF tumor suppressor.3
233778852013Polypeptide chain release factor eRF3 is a novel molecular partner of survivin.4
233778852013Polypeptide chain release factor eRF3 is a novel molecular partner of survivin.4
194171052009Structural insights into eRF3 and stop codon recognition by eRF1.76
194171052009Structural insights into eRF3 and stop codon recognition by eRF1.76
159879982005Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.47
159879982005Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.47

Citation

Dessen P

GSPT2 (G1 to S phase transition 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46632/js/lib/haematological-explorer/teaching-explorer/