HDAC7 (histone deacetylase 7)

2007-04-01  

Identity

HGNC
HDAC7
LOCATION
12q13.11
LOCUSID
51564
ALIAS
HD7,HD7A,HDAC7A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51564
MIM: 606542
HGNC: 14067
Ensembl: ENSG00000061273

Variants:

dbSNP: 51564
ClinVar: 51564
TCGA: ENSG00000061273
COSMIC: HDAC7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000061273ENST00000080059Q8WUI4
ENSG00000061273ENST00000354334Q8WUI4
ENSG00000061273ENST00000380610J3KPH8
ENSG00000061273ENST00000417107C9JZ79
ENSG00000061273ENST00000417902C9JVZ1
ENSG00000061273ENST00000421231C9J102
ENSG00000061273ENST00000422254C9JF80
ENSG00000061273ENST00000425451C9JKN3
ENSG00000061273ENST00000427332Q8WUI4
ENSG00000061273ENST00000430670C9JEB6
ENSG00000061273ENST00000433685C9JGF5
ENSG00000061273ENST00000434070C9JNI4
ENSG00000061273ENST00000440293C9JAH2
ENSG00000061273ENST00000445237C9JH46
ENSG00000061273ENST00000447463C9JNI4
ENSG00000061273ENST00000450805C9JBC2
ENSG00000061273ENST00000477203F8VWY3
ENSG00000061273ENST00000485796H0YI41
ENSG00000061273ENST00000488927A0A087WYQ4
ENSG00000061273ENST00000547259H0YHJ5
ENSG00000061273ENST00000548080H0YH91
ENSG00000061273ENST00000548938H0YI15
ENSG00000061273ENST00000552960Q8WUI4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947

References

Pubmed IDYearTitleCitations
353033812023Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease.13
375077702023Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.0
379607662023Comprehensive analysis of HDAC7 expression and its prognostic value in diffuse large B cell lymphoma: A review.1
353033812023Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease.13
375077702023Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.0
379607662023Comprehensive analysis of HDAC7 expression and its prognostic value in diffuse large B cell lymphoma: A review.1
355957352022WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.8
361630812022Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability.8
355957352022WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.8
361630812022Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability.8
332625262021HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia.6
337348982021Histone Deacetylase 7 Gene Overexpression Is Associated with Poor Prognosis of Triple-Negative Breast Cancer Patients.5
338788912021A regulative epigenetic circuit supervised by HDAC7 represses IGFBP6 and IGFBP7 expression to sustain mammary stemness.0
340113842021Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation.6
332625262021HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia.6

Citation

Dessen P

HDAC7 (histone deacetylase 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46734/teaching-explorer/gene-fusions/favicon/gene-fusions-explorer/