AKAP4 (A-kinase anchoring protein 4)

2007-04-01  

Identity

HGNC
AKAP4
LOCATION
Xp11.22
LOCUSID
8852
ALIAS
AKAP 82,AKAP-4,AKAP82,CT99,FSC1,HI,PRKA4,hAKAP82,p82
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8852
MIM: 300185
HGNC: 374
Ensembl: ENSG00000147081

Variants:

dbSNP: 8852
ClinVar: 8852
TCGA: ENSG00000147081
COSMIC: AKAP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147081ENST00000358526Q5JQC9
ENSG00000147081ENST00000358526A0A384MQY7
ENSG00000147081ENST00000376064Q5JQC9
ENSG00000147081ENST00000437370A0A075B6R4
ENSG00000147081ENST00000448865A0A075B6Q6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352536252022Silencing of A-kinase anchor protein 4 inhibits the metastasis and growth of non-small cell lung cancer.2
359674022022Identification of CD8(+) T-cell epitope from multiple myeloma-specific antigen AKAP4.1
352536252022Silencing of A-kinase anchor protein 4 inhibits the metastasis and growth of non-small cell lung cancer.2
359674022022Identification of CD8(+) T-cell epitope from multiple myeloma-specific antigen AKAP4.1
344096592021A new hemizygous missense mutation, c.454T＞C (p.S152P), in AKAP4 gene is associated with asthenozoospermia.2
344153202021Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development.14
344096592021A new hemizygous missense mutation, c.454T＞C (p.S152P), in AKAP4 gene is associated with asthenozoospermia.2
344153202021Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development.14
323427322020Knockdown of A-kinase anchor protein 4 inhibits proliferation of triple-negative breast cancer cells in vitro and in vivo.4
323427322020Knockdown of A-kinase anchor protein 4 inhibits proliferation of triple-negative breast cancer cells in vitro and in vivo.4
294806652018AKAP4, SPAG9 and NY-ESO-1 in Iranian Colorectal Cancer Patients as Probable Diagnostic and Prognostic Biomarkers.8
295813872018RNASET2 impairs the sperm motility via PKA/PI3K/calcium signal pathways.9
299844772018A-kinase anchor protein 4 precursor (pro-AKAP4) in human spermatozoa.15
301458362018Knockdown of A-kinase anchor protein 4 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in human gastric cancer cells.3
305452232018Down-regulation of TSGA10, AURKC, OIP5 and AKAP4 genes by Lactobacillus rhamnosus GG and Lactobacillus crispatus SJ-3C-US supernatants in HeLa cell line.0

Citation

Dessen P

AKAP4 (A-kinase anchoring protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46741/case-report-explorer/css/haematological-explorer/