IER5 (immediate early response 5)

2007-04-01  

Identity

HGNC
IER5
LOCATION
1q25.3
LOCUSID
51278
ALIAS
SBBI48

Other Information

Locus ID:

NCBI: 51278
MIM: 607177
HGNC: 5393
Ensembl: ENSG00000162783

Variants:

dbSNP: 51278
ClinVar: 51278
TCGA: ENSG00000162783
COSMIC: IER5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162783ENST00000367577Q5VY09

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
360475622023PP2A-B55 and its adapter proteins IER2 and IER5 regulate the activity of RB family proteins and the expression of cell cycle-related genes.4
360475622023PP2A-B55 and its adapter proteins IER2 and IER5 regulate the activity of RB family proteins and the expression of cell cycle-related genes.4
316697442020Nuclear import of IER5 is mediated by a classical bipartite nuclear localization signal and is required for HSF1 full activation.7
324715082020Novel role of PAF1 in attenuating radiosensitivity in cervical cancer by inhibiting IER5 transcription.6
329360722020IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation.11
316697442020Nuclear import of IER5 is mediated by a classical bipartite nuclear localization signal and is required for HSF1 full activation.7
324715082020Novel role of PAF1 in attenuating radiosensitivity in cervical cancer by inhibiting IER5 transcription.6
329360722020IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation.11
305992132019IER family proteins are regulators of protein phosphatase PP2A and modulate the phosphorylation status of CDC25A.6
305992132019IER family proteins are regulators of protein phosphatase PP2A and modulate the phosphorylation status of CDC25A.6
284305892017IER5 as a promising predictive marker promotes irradiation-induced apoptosis in cervical cancer tissues from patients undergoing chemoradiotherapy.5
291044872017IER5 is involved in DNA Double-Strand Breaks Repair in Association with PAPR1 in Hela Cells.8
284305892017IER5 as a promising predictive marker promotes irradiation-induced apoptosis in cervical cancer tissues from patients undergoing chemoradiotherapy.5
291044872017IER5 is involved in DNA Double-Strand Breaks Repair in Association with PAPR1 in Hela Cells.8
267549252016IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.29

Citation

Dessen P

IER5 (immediate early response 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46759/meetings/haematological-explorer/