HDAC8 (histone deacetylase 8)

2007-04-01  

Identity

HGNC
HDAC8
LOCATION
Xq13.1
LOCUSID
55869
ALIAS
CDA07,CDLS5,HD8,HDACL1,KDAC8,MRXS6,RPD3,WTS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55869
MIM: 300269
HGNC: 13315
Ensembl: ENSG00000147099

Variants:

dbSNP: 55869
ClinVar: 55869
TCGA: ENSG00000147099
COSMIC: HDAC8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147099ENST00000373554Q9BY41
ENSG00000147099ENST00000373556Q9BY41
ENSG00000147099ENST00000373559Q9BY41
ENSG00000147099ENST00000373560A6NGT0
ENSG00000147099ENST00000373568A6NGJ7
ENSG00000147099ENST00000373571A6NMT1
ENSG00000147099ENST00000373573Q9BY41
ENSG00000147099ENST00000373583A6NFW1
ENSG00000147099ENST00000373589Q9BY41
ENSG00000147099ENST00000412342F8WCG4
ENSG00000147099ENST00000415409E7EVA8
ENSG00000147099ENST00000421523C9J8F0
ENSG00000147099ENST00000436675E7EW22
ENSG00000147099ENST00000439122Q9BY41
ENSG00000147099ENST00000470998A0A3B3ISP0
ENSG00000147099ENST00000647594A0A3B3IRI9
ENSG00000147099ENST00000647606A0A3B3ISB8
ENSG00000147099ENST00000647654A0A3B3IT30
ENSG00000147099ENST00000647859A0A3B3IRI9
ENSG00000147099ENST00000647886A0A3B3IS68
ENSG00000147099ENST00000647974A0A3B3ISG7
ENSG00000147099ENST00000647980A0A3B3ITZ3
ENSG00000147099ENST00000648036A0A3B3IRZ8
ENSG00000147099ENST00000648139A0A3B3IRJ3
ENSG00000147099ENST00000648276A0A3B3IT98
ENSG00000147099ENST00000648298A0A3B3IRP8
ENSG00000147099ENST00000648452A0A3B3ISJ4
ENSG00000147099ENST00000648459A0A3B3IU52
ENSG00000147099ENST00000648504A0A3B3IT95
ENSG00000147099ENST00000648577A0A3B3IRJ8
ENSG00000147099ENST00000648711A0A3B3IU62
ENSG00000147099ENST00000648731A0A3B3ITV2
ENSG00000147099ENST00000648834A0A3B3ISS7
ENSG00000147099ENST00000648850A0A3B3ISN6
ENSG00000147099ENST00000648870A0A3B3IT84
ENSG00000147099ENST00000648939A0A3B3ISS7
ENSG00000147099ENST00000648962A0A3B3ISY0
ENSG00000147099ENST00000649097A0A3B3IT04
ENSG00000147099ENST00000649116Q9BY41
ENSG00000147099ENST00000649181A0A3B3IUD1
ENSG00000147099ENST00000649242A0A3B3IRJ8
ENSG00000147099ENST00000649274A0A3B3IS08
ENSG00000147099ENST00000649518A0A3B3IRJ8
ENSG00000147099ENST00000649543A0A3B3IRJ8
ENSG00000147099ENST00000649752A0A3B3ISE4
ENSG00000147099ENST00000650076A0A3B3IRZ0
ENSG00000147099ENST00000650126A0A3B3IU01
ENSG00000147099ENST00000650471A0A3B3IU21
ENSG00000147099ENST00000650604A0A3B3IS37
ENSG00000147099ENST00000650636A0A3B3IS93

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381510172024hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.3
381510172024hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.3
362502862023Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages.2
369117462023Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization.5
372277322023HDAC8 as an emerging target in drug discovery with special emphasis on medicinal chemistry.0
380305962023HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis.2
381821512023Activation of HDAC8 Can Suppress the Proliferation of Osteosarcoma Cells via TP53 and STAT3/ERK Signaling Pathways.0
362502862023Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages.2
369117462023Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization.5
372277322023HDAC8 as an emerging target in drug discovery with special emphasis on medicinal chemistry.0
380305962023HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis.2
381821512023Activation of HDAC8 Can Suppress the Proliferation of Osteosarcoma Cells via TP53 and STAT3/ERK Signaling Pathways.0
357777982022PHF5A Contributes to the Maintenance of the Cancer Stem-like Phenotype in Non-Small Cell Lung Cancer by Regulating Histone Deacetylase 8.5
357777982022PHF5A Contributes to the Maintenance of the Cancer Stem-like Phenotype in Non-Small Cell Lung Cancer by Regulating Histone Deacetylase 8.5
330983472021Alternative genomic diagnoses for individuals with a clinical diagnosis of Dubowitz syndrome.8

Citation

Dessen P

HDAC8 (histone deacetylase 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46856/css/cancer-prone-explorer/tumors-explorer/