DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)

2007-04-01  

Identity

HGNC
DNAJA2
LOCATION
16q11.2
LOCUSID
10294
ALIAS
CPR3,DJ3,DJA2,DNAJ,DNJ3,HIRIP4,PRO3015,RDJ2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10294
MIM: 611322
HGNC: 14884
Ensembl: ENSG00000069345

Variants:

dbSNP: 10294
ClinVar: 10294
TCGA: ENSG00000069345
COSMIC: DNAJA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069345ENST00000317089O60884
ENSG00000069345ENST00000317089A0A024R6S1
ENSG00000069345ENST00000563158I3L320
ENSG00000069345ENST00000617000A0A087WT48

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376407082023DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability.3
376700292023The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70.5
376407082023DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability.3
376700292023The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70.5
332295602020Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles.29
332295602020Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles.29
313958862019Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.31
314085072019Hsp70 and DNAJA2 limit CFTR levels through degradation.19
313958862019Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.31
314085072019Hsp70 and DNAJA2 limit CFTR levels through degradation.19
243188772014Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.81
243188772014Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.81
230910612012The DNAJA2 substrate release mechanism is essential for chaperone-mediated folding.26
230910612012The DNAJA2 substrate release mechanism is essential for chaperone-mediated folding.26
199401152010Hsp40 chaperones promote degradation of the HERG potassium channel.51

Citation

Dessen P

DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46879/favicon/meetings/js/lib/gene-fusions/?id=46879