CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2)

2007-04-01  

Identity

HGNC
CDK5R2
LOCATION
2q35
LOCUSID
8941
ALIAS
NCK5AI,P39,p39nck5ai
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8941
MIM: 603764
HGNC: 1776
Ensembl: ENSG00000171450

Variants:

dbSNP: 8941
ClinVar: 8941
TCGA: ENSG00000171450
COSMIC: CDK5R2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171450ENST00000302625Q13319

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
304524902018Hyper-phosphorylation of Rb S249 together with CDK5R2/p39 overexpression are associated with impaired cell adhesion and epithelial-to-mesenchymal transition: Implications as a potential lung cancer grading and staging biomarker.5
304524902018Hyper-phosphorylation of Rb S249 together with CDK5R2/p39 overexpression are associated with impaired cell adhesion and epithelial-to-mesenchymal transition: Implications as a potential lung cancer grading and staging biomarker.5
251288172015The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens.10
251288172015The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens.10
240853002013Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.6
240853002013Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.6
209363772011Decreased expression of p39 is associated with a poor prognosis in human hepatocellular carcinoma.10
209363772011Decreased expression of p39 is associated with a poor prognosis in human hepatocellular carcinoma.10
205184842010Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.28
205184842010Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.28
159170972005Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.15
159170972005Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.15
117847202002Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29.34
117847202002Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29.34

Citation

Dessen P

CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46984/teaching-explorer/hgnc