RNF41 (ring finger protein 41)

2007-04-01  

Identity

HGNC
RNF41
LOCATION
12q13.3
LOCUSID
10193
ALIAS
FLRF,NRDP1,SBBI03
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10193
HGNC: 18401
Ensembl: ENSG00000181852

Variants:

dbSNP: 10193
ClinVar: 10193
TCGA: ENSG00000181852
COSMIC: RNF41

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181852ENST00000345093Q9H4P4
ENSG00000181852ENST00000345093A0A024RB33
ENSG00000181852ENST00000394013Q9H4P4
ENSG00000181852ENST00000547967F8VVY2
ENSG00000181852ENST00000549038F8VSP7
ENSG00000181852ENST00000549119F8VSE5
ENSG00000181852ENST00000551711F8VNZ6
ENSG00000181852ENST00000552244F8VSB6
ENSG00000181852ENST00000552656Q9H4P4
ENSG00000181852ENST00000552656A0A024RB33
ENSG00000181852ENST00000615206Q9H4P4
ENSG00000181852ENST00000615206A0A024RB33

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB2REACTOMER-HSA-1227986
Downregulation of ERBB2:ERBB3 signalingREACTOMER-HSA-1358803
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385834432024Correlation between neuregulin receptor degradation protein-1 and Crohn's disease.0
386541082024VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane.0
385834432024Correlation between neuregulin receptor degradation protein-1 and Crohn's disease.0
386541082024VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane.0
364467792022m(6)A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation.9
364467792022m(6)A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation.9
342707062021Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5.1
342707062021Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5.1
291803532018Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates β-Cell Mitophagy.29
294103452018Decreased RNF41 expression leads to insulin resistance in skeletal muscle of obese women.1
303676232018Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer.13
291803532018Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates β-Cell Mitophagy.29
294103452018Decreased RNF41 expression leads to insulin resistance in skeletal muscle of obese women.1
303676232018Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer.13
276489362017KITENIN functions as a fine regulator of ErbB4 expression level in colorectal cancer via protection of ErbB4 from E3-ligase Nrdp1-mediated degradation.13

Citation

Dessen P

RNF41 (ring finger protein 41)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47099/gene-explorer/haematological-explorer/humanGenome