GPS1 (G protein pathway suppressor 1)

2007-04-01 Affiliation

Identity

HGNC

GPS1

LOCATION

17q25.3

LOCUSID

2873

ALIAS

COPS1,CSN1,SGN1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2873
MIM: 601934
HGNC: 4549
Ensembl: ENSG00000169727

Variants:

dbSNP: 2873
ClinVar: 2873
TCGA: ENSG00000169727
COSMIC: GPS1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000169727	ENST00000306823	Q13098
ENSG00000169727	ENST00000320548	C9JFE4
ENSG00000169727	ENST00000392358	Q13098
ENSG00000169727	ENST00000578168	J3QQX0
ENSG00000169727	ENST00000578392	J3KSY1
ENSG00000169727	ENST00000578552	Q13098
ENSG00000169727	ENST00000580141	J3KRY5
ENSG00000169727	ENST00000580627	J3QQP2
ENSG00000169727	ENST00000580716	J3QLT0
ENSG00000169727	ENST00000580723	J3KRY5
ENSG00000169727	ENST00000581418	J3KTB0
ENSG00000169727	ENST00000581578	J3QS84
ENSG00000169727	ENST00000582327	J3QS88
ENSG00000169727	ENST00000583009	J3QLE8
ENSG00000169727	ENST00000583641	J3KRJ4
ENSG00000169727	ENST00000583885	J3KRE8
ENSG00000169727	ENST00000583961	J3QL53
ENSG00000169727	ENST00000584460	J3KRY5
ENSG00000169727	ENST00000585084	J3KSA5
ENSG00000169727	ENST00000623691	A0A096LP07
ENSG00000169727	ENST00000623761	A8K070
ENSG00000169727	ENST00000624957	A0A096LPJ3

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
DNA Repair	REACTOME	R-HSA-73894
Nucleotide Excision Repair	REACTOME	R-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)	REACTOME	R-HSA-5696399
DNA Damage Recognition in GG-NER	REACTOME	R-HSA-5696394
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	REACTOME	R-HSA-6781827
Formation of TC-NER Pre-Incision Complex	REACTOME	R-HSA-6781823
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825

References

Pubmed ID	Year	Title	Citations
38289496	2024	Bioinformatics analysis of GPS1 expression and biological function in breast cancer.	0
38289496	2024	Bioinformatics analysis of GPS1 expression and biological function in breast cancer.	0
33200803	2021	CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression.	8
33200803	2021	CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression.	8
26986008	2016	UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis.	4
27325650	2016	CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.	22
26986008	2016	UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis.	4
27325650	2016	CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.	22
23408908	2013	Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome.	25
23408908	2013	Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome.	25
22103747	2012	Altered expression of COP9 signalosome proteins in preeclampsia.	5
22103747	2012	Altered expression of COP9 signalosome proteins in preeclampsia.	5
21604193	2011	CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1.	5
21604193	2011	CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1.	5
11114242	2001	The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.	36

Citation

Dessen P

GPS1 (G protein pathway suppressor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47118/js/css/lib/hgnc