EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit)

2007-04-01  

Identity

HGNC
EZH1
LOCATION
17q21.2
LOCUSID
2145
ALIAS
KMT6B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2145
MIM: 601674
HGNC: 3526
Ensembl: ENSG00000108799

Variants:

dbSNP: 2145
ClinVar: 2145
TCGA: ENSG00000108799
COSMIC: EZH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108799ENST00000415827A0A0A0MSY9
ENSG00000108799ENST00000428826Q92800
ENSG00000108799ENST00000585893Q92800
ENSG00000108799ENST00000586089K7EM79
ENSG00000108799ENST00000586382K7EIH5
ENSG00000108799ENST00000586867K7EJU6
ENSG00000108799ENST00000586935K7EK26
ENSG00000108799ENST00000588239K7ESB9
ENSG00000108799ENST00000588897K7ENP2
ENSG00000108799ENST00000590078Q92800
ENSG00000108799ENST00000592492K7EK66
ENSG00000108799ENST00000592743Q92800
ENSG00000108799ENST00000593214K7EPC0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383096752024The competitive mechanism of EZH1 and EZH2 in promoting oral squamous cell carcinoma.0
385544272024Clinical Significance of Upregulation of EZH1 Expression in Hepatocellular Carcinoma Tissues.0
383096752024The competitive mechanism of EZH1 and EZH2 in promoting oral squamous cell carcinoma.0
385544272024Clinical Significance of Upregulation of EZH1 Expression in Hepatocellular Carcinoma Tissues.0
374337832023Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders.5
374337832023Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders.5
348564182022TRIM21 improves apatinib treatment in gastric cancer through suppressing EZH1 stability.9
358468802022Downregulation of the enhancer of zeste homolog 1 transcriptional factor predicts poor prognosis of triple-negative breast cancer patients.1
360527162022Polycomb EZH1 regulates cell cycle/5-fluorouracil sensitivity of neuroblastoma cells in concert with MYCN.2
364762712022The role of EZH1 and EZH2 in development and cancer.7
348564182022TRIM21 improves apatinib treatment in gastric cancer through suppressing EZH1 stability.9
358468802022Downregulation of the enhancer of zeste homolog 1 transcriptional factor predicts poor prognosis of triple-negative breast cancer patients.1
360527162022Polycomb EZH1 regulates cell cycle/5-fluorouracil sensitivity of neuroblastoma cells in concert with MYCN.2
364762712022The role of EZH1 and EZH2 in development and cancer.7
335147052021Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.30

Citation

Dessen P

EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47297/gene-fusions-explorer/meetings/cancer-prone-explorer/