CNP (2,3-cyclic nucleotide 3 phosphodiesterase)

2007-04-01  

Identity

HGNC
CNP
LOCATION
17q21.2
LOCUSID
1267
ALIAS
CNP1,HLD20
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1267
MIM: 123830
HGNC: 2158
Ensembl: ENSG00000173786

Variants:

dbSNP: 1267
ClinVar: 1267
TCGA: ENSG00000173786
COSMIC: CNP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173786ENST00000393888P09543
ENSG00000173786ENST00000393888A0A024R1T5
ENSG00000173786ENST00000393892P09543
ENSG00000173786ENST00000441615C9K0L8
ENSG00000173786ENST00000472031K7EQ27
ENSG00000173786ENST00000585452K7ERZ0
ENSG00000173786ENST00000587679K7ERC4
ENSG00000173786ENST00000589772K7EN66

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
bone marrow

References

Pubmed IDYearTitleCitations
336533722021Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts.15
336533722021Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts.15
321286162020CNP deficiency causes severe hypomyelinating leukodystrophy in humans.11
321286162020CNP deficiency causes severe hypomyelinating leukodystrophy in humans.11
310904552019Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.10
3161726620192',3'-Cyclic-nucleotide 3'-phosphodiesterase contributes to epithelial-mesenchymal transition of lens epithelial cells through the notch signalling pathway.3
310904552019Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.10
3161726620192',3'-Cyclic-nucleotide 3'-phosphodiesterase contributes to epithelial-mesenchymal transition of lens epithelial cells through the notch signalling pathway.3
303557382018The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress.8
303557382018The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress.8
259300752015Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder.39
259300752015Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder.39
248085402014Role of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the renal 2',3'-cAMP-adenosine pathway.8
248085402014Role of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the renal 2',3'-cAMP-adenosine pathway.8
229546682013CNP and DPYSL2 mRNA expression and promoter methylation levels in brain of Alzheimer's disease patients.12

Citation

Dessen P

CNP (2,3-cyclic nucleotide 3 phosphodiesterase)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47306/gene-fusions/js/tumors-explorer/