PLEKHA7 (pleckstrin homology domain containing A7)

2007-04-01  

Identity

HGNC
LOCATION
11p15.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 144100
MIM: 612686
HGNC: 27049
Ensembl: ENSG00000166689

Variants:

dbSNP: 144100
ClinVar: 144100
TCGA: ENSG00000166689
COSMIC: PLEKHA7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166689ENST00000355661Q6IQ23
ENSG00000166689ENST00000525581E9PL74
ENSG00000166689ENST00000528376E9PIK1
ENSG00000166689ENST00000530489H0YDE2
ENSG00000166689ENST00000531066E9PKC0
ENSG00000166689ENST00000532079E9PN45
ENSG00000166689ENST00000636090A0A1B0GUM1
ENSG00000166689ENST00000636113A0A1B0GUN0
ENSG00000166689ENST00000637162A0A1B0GTN9

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
368233762023The hTERT-p50 homodimer inhibits PLEKHA7 expression to promote gastric cancer invasion and metastasis.0
368233762023The hTERT-p50 homodimer inhibits PLEKHA7 expression to promote gastric cancer invasion and metastasis.0
357147712022The PLEKHA7-PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells.1
357147712022The PLEKHA7-PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells.1
335253802021PLEKHA7, an Apical Adherens Junction Protein, Suppresses Inflammatory Breast Cancer in the Context of High E-Cadherin and p120-Catenin Expression.7
338782922021Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.11
346137982021PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis.17
348005422021PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer.0
335253802021PLEKHA7, an Apical Adherens Junction Protein, Suppresses Inflammatory Breast Cancer in the Context of High E-Cadherin and p120-Catenin Expression.7
338782922021Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.11
346137982021PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis.17
348005422021PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer.0
323713902020Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33.6
323713902020Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33.6
290168602017Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function.10

Citation

Dessen P

PLEKHA7 (pleckstrin homology domain containing A7)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47399/gene-explorer/gene-fusions-explorer/