UBE2G1 (ubiquitin conjugating enzyme E2 G1)

2007-04-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
E217K,UBC7,UBE2G
FUSION GENES

Other Information

Locus ID:

NCBI: 7326
MIM: 601569
HGNC: 12482
Ensembl: ENSG00000132388

Variants:

dbSNP: 7326
ClinVar: 7326
TCGA: ENSG00000132388
COSMIC: UBE2G1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132388ENST00000396981P62253
ENSG00000132388ENST00000571953K7EPR7
ENSG00000132388ENST00000571980I3L2Q4
ENSG00000132388ENST00000572484I3L2H7
ENSG00000132388ENST00000574633I3L0Q0

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Parkinson's diseaseKEGGhsa05012
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
318685892019Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.28
318685892019Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.28
302344872018UBE2G1 governs the destruction of cereblon neomorphic substrates.35
302344872018UBE2G1 governs the destruction of cereblon neomorphic substrates.35
254713712015Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.17
254713712015Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.17
216285272011Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.28
216285272011Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.28
129339042003Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.26
129339042003Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.26

Citation

Dessen P

UBE2G1 (ubiquitin conjugating enzyme E2 G1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47405/teaching-explorer/js/gene-explorer/