PHC3 (polyhomeotic homolog 3)

2007-04-01  

Identity

HGNC
PHC3
LOCATION
3q26.2
LOCUSID
80012
ALIAS
EDR3,HPH3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80012
HGNC: 15682
Ensembl: ENSG00000173889

Variants:

dbSNP: 80012
ClinVar: 80012
TCGA: ENSG00000173889
COSMIC: PHC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173889ENST00000466189C9J6H0
ENSG00000173889ENST00000467570E7EX82
ENSG00000173889ENST00000472330F8WDA4
ENSG00000173889ENST00000475729C9JYH7
ENSG00000173889ENST00000479467B4DTC4
ENSG00000173889ENST00000481639G5E9U7
ENSG00000173889ENST00000484068H7C528
ENSG00000173889ENST00000484931C9JAU4
ENSG00000173889ENST00000486042H7C4H9
ENSG00000173889ENST00000494943Q8NDX5
ENSG00000173889ENST00000495893Q8NDX5
ENSG00000173889ENST00000497658Q8NDX5

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374689932023Expression of circ-PHC3 enhances ovarian cancer progression via regulation of the miR-497-5p/SOX9 pathway.1
374689932023Expression of circ-PHC3 enhances ovarian cancer progression via regulation of the miR-497-5p/SOX9 pathway.1
263433562015Polycomb genes are associated with response to imatinib in chronic myeloid leukemia.8
263433562015Polycomb genes are associated with response to imatinib in chronic myeloid leukemia.8
239420792013Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration.5
239420792013Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration.5
227244432012Human polyhomeotic homolog 3 (PHC3) sterile alpha motif (SAM) linker allows open-ended polymerization of PHC3 SAM.7
227244432012Human polyhomeotic homolog 3 (PHC3) sterile alpha motif (SAM) linker allows open-ended polymerization of PHC3 SAM.7
204917732010Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma.15
204917732010Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma.15
170013162007PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors.29
170013162007PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors.29

Citation

Dessen P

PHC3 (polyhomeotic homolog 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47433/js/lib/tumors-explorer/welcome