WWP2 (WW domain containing E3 ubiquitin protein ligase 2)

2007-04-01  

Identity

HGNC
WWP2
LOCATION
16q22.1
LOCUSID
11060
ALIAS
AIP2,WWp2-like
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11060
MIM: 602308
HGNC: 16804
Ensembl: ENSG00000198373

Variants:

dbSNP: 11060
ClinVar: 11060
TCGA: ENSG00000198373
COSMIC: WWP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198373ENST00000356003O00308
ENSG00000198373ENST00000359154O00308
ENSG00000198373ENST00000359154A0A024R711
ENSG00000198373ENST00000561780H3BRX8
ENSG00000198373ENST00000563659H3BPJ8
ENSG00000198373ENST00000568684O00308
ENSG00000198373ENST00000569174O00308
ENSG00000198373ENST00000569620H3BS79

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120

References

Pubmed IDYearTitleCitations
379212192024WWP2 binds to NKRF, enhances the NF-κB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells.0
379212192024WWP2 binds to NKRF, enhances the NF-κB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells.0
362087152023WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes.3
367733332023Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.1
367957542023lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1.9
368033682023WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.3
371496682023Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X.2
362087152023WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes.3
367733332023Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.1
367957542023lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1.9
368033682023WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.3
371496682023Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X.2
353317372022Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates.4
358808372022WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma.3
359839772022WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway.4

Citation

Dessen P

WWP2 (WW domain containing E3 ubiquitin protein ligase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47485/favicon/js/gene-fusions/?id=47485