PFKM (phosphofructokinase, muscle)

2007-04-01 Affiliation

Identity

HGNC

PFKM

LOCATION

12q13.11

LOCUSID

5213

ALIAS

ATP-PFK,GSD7,PFK-1,PFK-A,PFK1,PFKA,PFKX,PPP1R122

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5213
MIM: 610681
HGNC: 8877
Ensembl: ENSG00000152556

Variants:

dbSNP: 5213
ClinVar: 5213
TCGA: ENSG00000152556
COSMIC: PFKM

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000152556	ENST00000312352	P08237
ENSG00000152556	ENST00000312352	A0A024R0Y5
ENSG00000152556	ENST00000340802	P08237
ENSG00000152556	ENST00000359794	P08237
ENSG00000152556	ENST00000359794	A0A024R0Y5
ENSG00000152556	ENST00000546465	F8VP00
ENSG00000152556	ENST00000546755	F8VNZ1
ENSG00000152556	ENST00000547066	F8VSF5
ENSG00000152556	ENST00000547581	F8VTT5
ENSG00000152556	ENST00000547587	P08237
ENSG00000152556	ENST00000547587	A0A024R0Y5
ENSG00000152556	ENST00000548288	F8VUB8
ENSG00000152556	ENST00000548345	F8VX13
ENSG00000152556	ENST00000549003	F8VW30
ENSG00000152556	ENST00000549022	F8VZQ1
ENSG00000152556	ENST00000549366	F8VVE3
ENSG00000152556	ENST00000549941	F8VZI0
ENSG00000152556	ENST00000550257	F8VTQ3
ENSG00000152556	ENST00000550345	P08237
ENSG00000152556	ENST00000550345	A0A024R0Y5
ENSG00000152556	ENST00000550924	P08237
ENSG00000152556	ENST00000550924	A0A024R0Y5
ENSG00000152556	ENST00000551339	P08237
ENSG00000152556	ENST00000551339	A0A024R0Y5
ENSG00000152556	ENST00000551485	F8VSF7
ENSG00000152556	ENST00000551804	P08237
ENSG00000152556	ENST00000551804	A0A0S2Z4I1
ENSG00000152556	ENST00000552752	H0YHB8
ENSG00000152556	ENST00000552792	F8VYK8
ENSG00000152556	ENST00000552989	F8VZ53
ENSG00000152556	ENST00000629846	F8VSF7
ENSG00000152556	ENST00000642730	A0A2R8Y891

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycolysis / Gluconeogenesis	KEGG	ko00010
Pentose phosphate pathway	KEGG	ko00030
Fructose and mannose metabolism	KEGG	ko00051
Galactose metabolism	KEGG	ko00052
Glycolysis / Gluconeogenesis	KEGG	hsa00010
Pentose phosphate pathway	KEGG	hsa00030
Fructose and mannose metabolism	KEGG	hsa00051
Galactose metabolism	KEGG	hsa00052
RNA degradation	KEGG	ko03018
RNA degradation	KEGG	hsa03018
Metabolic pathways	KEGG	hsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate	KEGG	hsa_M00001
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate	KEGG	M00001
Biosynthesis of amino acids	KEGG	hsa01230
Biosynthesis of amino acids	KEGG	ko01230
Carbon metabolism	KEGG	hsa01200
Carbon metabolism	KEGG	ko01200
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Central carbon metabolism in cancer	KEGG	hsa05230
Central carbon metabolism in cancer	KEGG	ko05230
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glucose metabolism	REACTOME	R-HSA-70326
Glycolysis	REACTOME	R-HSA-70171

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36601784	2023	RNAi screening reveals a synthetic chemical-genetic interaction between ATP synthase and PFK1 in cancer cells.	2
37622331	2023	Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity.	2
36601784	2023	RNAi screening reveals a synthetic chemical-genetic interaction between ATP synthase and PFK1 in cancer cells.	2
37622331	2023	Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity.	2
35328104	2022	Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer Patients.	6
35838787	2022	Association of PFKM gene polymorphisms and susceptibility to cryptorchidism in a Chinese Han population.	0
36253358	2022	Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM.	7
35328104	2022	Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer Patients.	6
35838787	2022	Association of PFKM gene polymorphisms and susceptibility to cryptorchidism in a Chinese Han population.	0
36253358	2022	Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM.	7
33404290	2021	RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2.	5
33516882	2021	PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells.	2
33897890	2021	ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM.	38
33404290	2021	RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2.	5
33516882	2021	PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells.	2

Citation

Dessen P

PFKM (phosphofructokinase, muscle)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47486/gene-fusions/js/gene-explorer/