COPS7B (COP9 signalosome subunit 7B)

2007-04-01  

Identity

HGNC
COPS7B
LOCATION
2q37.1
LOCUSID
64708
ALIAS
CSN7B,SGN7b
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64708
MIM: 616010
HGNC: 16760
Ensembl: ENSG00000144524

Variants:

dbSNP: 64708
ClinVar: 64708
TCGA: ENSG00000144524
COSMIC: COPS7B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144524ENST00000350033Q9H9Q2
ENSG00000144524ENST00000350033A0A024R471
ENSG00000144524ENST00000357490J3KQV6
ENSG00000144524ENST00000373608Q9H9Q2
ENSG00000144524ENST00000409091Q9H9Q2
ENSG00000144524ENST00000409091A0A024R478
ENSG00000144524ENST00000409295J3KQ34
ENSG00000144524ENST00000410017J3KQ41
ENSG00000144524ENST00000410024Q9H9Q2
ENSG00000144524ENST00000410024A0A024R471
ENSG00000144524ENST00000412591J3QT95
ENSG00000144524ENST00000412922J3QT43
ENSG00000144524ENST00000413197J3QT67
ENSG00000144524ENST00000432387J3QT50
ENSG00000144524ENST00000436564J3QT65
ENSG00000144524ENST00000449174J3QT73
ENSG00000144524ENST00000449784J3KQV6
ENSG00000144524ENST00000450501J3QT66
ENSG00000144524ENST00000452375J3QT69
ENSG00000144524ENST00000611614A0A087X1P5
ENSG00000144524ENST00000620578Q9H9Q2
ENSG00000144524ENST00000620578A0A024R478
ENSG00000144524ENST00000631349J3QT66

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375609712023The IGF2BP3-COPS7B Axis Facilitates mRNA Translation to Drive Colorectal Cancer Progression.2
375609712023The IGF2BP3-COPS7B Axis Facilitates mRNA Translation to Drive Colorectal Cancer Progression.2
335034272021CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response.4
335034272021CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response.4

Citation

Dessen P

COPS7B (COP9 signalosome subunit 7B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47495/case-report-explorer/js/lib/teaching-explorer/