RSPO2 (R-spondin 2)

2007-04-01  

Identity

HGNC
RSPO2
LOCATION
8q23.1
LOCUSID
340419
ALIAS
CRISTIN2,HHRRD,TETAMS2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 340419
MIM: 610575
HGNC: 28583
Ensembl: ENSG00000147655

Variants:

dbSNP: 340419
ClinVar: 340419
TCGA: ENSG00000147655
COSMIC: RSPO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147655ENST00000276659Q6UXX9
ENSG00000147655ENST00000517781Q6UXX9
ENSG00000147655ENST00000517939Q6UXX9
ENSG00000147655ENST00000521956E5RH25
ENSG00000147655ENST00000522333E5RGU9
ENSG00000147655ENST00000666252A0A590UJ52

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362150262023Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease.3
362150262023Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease.3
348470792022RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.19
350277682022Identification of a regulatory pathway inhibiting adipogenesis via RSPO2.24
348470792022RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.19
350277682022Identification of a regulatory pathway inhibiting adipogenesis via RSPO2.24
327501062021Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.20
333207372021R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.6
342733742021RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3/Hedgehog-Gli1 signal pathway.3
344073992021RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia.12
345732752021Evaluation of WNT Signaling Pathway Gene Variants WNT7B rs6519955, SFRP4 rs17171229 and RSPO2 rs611744 in Patients with Dupuytren's Contracture.1
327501062021Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.20
333207372021R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.6
342733742021RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3/Hedgehog-Gli1 signal pathway.3
344073992021RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia.12

Citation

Dessen P

RSPO2 (R-spondin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47520/teaching-explorer/humanGenome