SPAG1 (sperm associated antigen 1)

2007-07-01  

Identity

HGNC
SPAG1
LOCATION
8q22.2
LOCUSID
6674
ALIAS
CILD28,CT140,DNAAF13,HEL-S-268,HSD-3.8,SP75,TPIS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6674
MIM: 603395
HGNC: 11212
Ensembl: ENSG00000104450

Variants:

dbSNP: 6674
ClinVar: 6674
TCGA: ENSG00000104450
COSMIC: SPAG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104450ENST00000251809Q07617
ENSG00000104450ENST00000388798Q07617
ENSG00000104450ENST00000520508Q07617
ENSG00000104450ENST00000520643Q07617

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
351785542022The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia.3
352272742022Comprehensive analysis of SPAG1 expression as a prognostic and predictive biomarker in acute myeloid leukemia by integrative bioinformatics and clinical validation.4
359514562022SPAG1 promotes the development of AML by activating the ERK/MAPK signaling pathway and affects the chemotherapy sensitivity of venetoclax.1
351785542022The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia.3
352272742022Comprehensive analysis of SPAG1 expression as a prognostic and predictive biomarker in acute myeloid leukemia by integrative bioinformatics and clinical validation.4
359514562022SPAG1 promotes the development of AML by activating the ERK/MAPK signaling pathway and affects the chemotherapy sensitivity of venetoclax.1
337390912021Optimizing the First TPR Domain of the Human SPAG1 Protein Provides Insight into the HSP70 and HSP90 Binding Properties.4
337390912021Optimizing the First TPR Domain of the Human SPAG1 Protein Provides Insight into the HSP70 and HSP90 Binding Properties.4
326195742020Bioinformatics analysis of the genes involved in the extension of prostate cancer to adjacent lymph nodes by supervised and unsupervised machine learning methods: The role of SPAG1 and PLEKHF2.11
326195742020Bioinformatics analysis of the genes involved in the extension of prostate cancer to adjacent lymph nodes by supervised and unsupervised machine learning methods: The role of SPAG1 and PLEKHF2.11
311182662019Binding properties of the quaternary assembly protein SPAG1.6
311182662019Binding properties of the quaternary assembly protein SPAG1.6
240551122013Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms.74
240551122013Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms.74
169833432007Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells.15

Citation

Dessen P

SPAG1 (sperm associated antigen 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47639/spag1-(sperm-associated-antigen-1)