HAVCR2 (hepatitis A virus cellular receptor 2)

2007-07-01  

Identity

HGNC
HAVCR2
LOCATION
5q33.3
LOCUSID
84868
ALIAS
CD366,HAVcr-2,KIM-3,SPTCL,TIM3,TIMD-3,TIMD3,Tim-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84868
MIM: 606652
HGNC: 18437
Ensembl: ENSG00000135077

Variants:

dbSNP: 84868
ClinVar: 84868
TCGA: ENSG00000135077
COSMIC: HAVCR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135077ENST00000307851Q8TDQ0
ENSG00000135077ENST00000522593E5RHN3
ENSG00000135077ENST00000524219E5RFR4

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377987542024Expression of B7-H3 and TIM-3 in gastric-type endocervical adenocarcinoma: prevalence, association with PD-L1 expression, and prognostic significance.0
380623352024T-cell Immunoglobulin and Mucin Domain 3 in Circulating Monocytes as a Novel Biomarker for Coronary Artery Disease.0
381083362024Activated Tim-3/Galectin-9 participated in the development of multiple myeloma by negatively regulating CD4 T cells.2
382679062024TIM-3/Galectin-9 interaction and glutamine metabolism in AML cell lines, HL-60 and THP-1.0
383695022024Diffuse large B-cell lymphoma: the significance of CD8(+) tumor-infiltrating lymphocytes exhaustion mediated by TIM3/Galectin-9 pathway.1
384575142024Beyond T cell exhaustion: TIM-3 regulation of myeloid cells.2
385360232024TIM3 and CTLA4 immune checkpoint polymorphisms are associated with acute myeloid leukemia in Saudi Arabia.0
385766062024The role of TIM-3 in sepsis: a promising target for immunotherapy?1
387230112024Association of tuberculosis risk with genetic polymorphisms of the immune checkpoint genes PDCD1, CTLA-4, and TIM3.0
388125112024A potential defensive role of TIM-3 on T lymphocytes in the inflammatory involvement of diabetic kidney disease.0
389242992024TIM-3 Expression in Endometriosis.0
377987542024Expression of B7-H3 and TIM-3 in gastric-type endocervical adenocarcinoma: prevalence, association with PD-L1 expression, and prognostic significance.0
380623352024T-cell Immunoglobulin and Mucin Domain 3 in Circulating Monocytes as a Novel Biomarker for Coronary Artery Disease.0
381083362024Activated Tim-3/Galectin-9 participated in the development of multiple myeloma by negatively regulating CD4 T cells.2
382679062024TIM-3/Galectin-9 interaction and glutamine metabolism in AML cell lines, HL-60 and THP-1.0

Citation

Dessen P

HAVCR2 (hepatitis A virus cellular receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47642/favicon/js/haematological-explorer/