REG3A (regenerating family member 3 alpha)

2003-02-01  

Identity

HGNC
LOCATION
2p12
LOCUSID
ALIAS
HIP,HIP/PAP,INGAP,PAP,PAP-H,PAP1,PBCGF,REG-III,REG3
FUSION GENES

Other Information

Locus ID:

NCBI: 5068
MIM: 167805
HGNC: 8601
Ensembl: ENSG00000172016

Variants:

dbSNP: 5068
ClinVar: 5068
TCGA: ENSG00000172016
COSMIC: REG3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172016ENST00000305165Q06141
ENSG00000172016ENST00000305165Q53S56
ENSG00000172016ENST00000393878Q06141
ENSG00000172016ENST00000393878Q53S56
ENSG00000172016ENST00000409839Q06141
ENSG00000172016ENST00000409839Q53S56

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370426182024REG3A overexpression functions as a negative predictive and prognostic biomarker in rectal cancer patients receiving CCRT.0
376651732024REG3A promotes proliferation and DDP resistance of ovarian cancer cells by activating the PI3K/Akt signaling pathway.1
388401452024Increased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cells.0
370426182024REG3A overexpression functions as a negative predictive and prognostic biomarker in rectal cancer patients receiving CCRT.0
376651732024REG3A promotes proliferation and DDP resistance of ovarian cancer cells by activating the PI3K/Akt signaling pathway.1
388401452024Increased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cells.0
375802682023[Effect of REG3A on proliferation and invasion of glioma cells by regulating PI3K/Akt signaling pathway].1
377088492023Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2.0
380117862023Tumor-suppressive effect of Reg3A in COAD is mediated by T cell activation in nude mice.0
375802682023[Effect of REG3A on proliferation and invasion of glioma cells by regulating PI3K/Akt signaling pathway].1
377088492023Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2.0
380117862023Tumor-suppressive effect of Reg3A in COAD is mediated by T cell activation in nude mice.0
345580592022Antimicrobial protein REG3A and signaling networks are predictive of stroke outcomes.5
348116362022The regenerating protein 3A: a crucial molecular with dual roles in cancer.1
350306292022Regenerating islet-derived protein 3-α is a prognostic biomarker for gastrointestinal chronic graft-versus-host disease.5

Citation

Dessen P

REG3A (regenerating family member 3 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/487/css/case-report-explorer/tumors-explorer/