RAMP2 (receptor activity modifying protein 2)

2007-11-01  

Identity

HGNC
RAMP2
LOCATION
17q21.2
LOCUSID
10266
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10266
MIM: 605154
HGNC: 9844
Ensembl: ENSG00000131477

Variants:

dbSNP: 10266
ClinVar: 10266
TCGA: ENSG00000131477
COSMIC: RAMP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131477ENST00000253796O60895
ENSG00000131477ENST00000253796A0A024R1Z2
ENSG00000131477ENST00000587142O60895
ENSG00000131477ENST00000588576K7EKQ3
ENSG00000131477ENST00000588928K7ENJ8
ENSG00000131477ENST00000589683K7EPN3

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Calcitonin-like ligand receptorsREACTOMER-HSA-419812
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

References

Pubmed IDYearTitleCitations
382795012023RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer.0
382795012023RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer.0
333853432021Adrenomedullin-Receptor Activity-Modifying Protein 2 System Ameliorates Subretinal Fibrosis by Suppressing Epithelial-Mesenchymal Transition in Age-Related Macular Degeneration.3
342712202021Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.14
333853432021Adrenomedullin-Receptor Activity-Modifying Protein 2 System Ameliorates Subretinal Fibrosis by Suppressing Epithelial-Mesenchymal Transition in Age-Related Macular Degeneration.3
342712202021Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.14
308262862019Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context.11
311504172019Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.9
308262862019Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context.11
311504172019Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.9
285864392017RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling.18
286146672017N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.11
289042532017Genetic Variants of RAMP2 and CLR are Associated with Stroke.9
285864392017RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling.18
286146672017N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.11

Citation

Dessen P

RAMP2 (receptor activity modifying protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49831/welcome