ROPN1 (rhophilin associated tail protein 1)

2007-12-01  

Identity

HGNC
ROPN1
LOCATION
3q21.1
LOCUSID
54763
ALIAS
CT91,ODF6,RHPNAP1,ROPN1A,ropporin
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54763
MIM: 611757
HGNC: 17692
Ensembl: ENSG00000065371

Variants:

dbSNP: 54763
ClinVar: 54763
TCGA: ENSG00000065371
COSMIC: ROPN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065371ENST00000184183Q9HAT0
ENSG00000065371ENST00000184183A0A140VKB2
ENSG00000065371ENST00000405845Q9HAT0
ENSG00000065371ENST00000405845A0A140VKB2
ENSG00000065371ENST00000459660Q9HAT0
ENSG00000065371ENST00000460743C9JP07
ENSG00000065371ENST00000467907C9J6H4
ENSG00000065371ENST00000479867Q9HAT0
ENSG00000065371ENST00000484329Q9HAT0
ENSG00000065371ENST00000495093Q9HAT0
ENSG00000065371ENST00000496145C9J012
ENSG00000065371ENST00000620893Q9HAT0
ENSG00000065371ENST00000620893A0A140VKB2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate Rhotekin and RhophilinsREACTOMER-HSA-5666185

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
324273992020Rhophilin-associated tail protein 1 promotes migration and metastasis in triple negative breast cancer via activation of RhoA.3
324273992020Rhophilin-associated tail protein 1 promotes migration and metastasis in triple negative breast cancer via activation of RhoA.3
292473442018Molecular study of human sperm RNA: Ropporin and CABYR in asthenozoospermia.12
292473442018Molecular study of human sperm RNA: Ropporin and CABYR in asthenozoospermia.12
257049932015Ropporin gene expression in infertile asthenozoospermic men with varicocele before and after repair.6
257049932015Ropporin gene expression in infertile asthenozoospermic men with varicocele before and after repair.6
220211752012Loss of ASP but not ROPN1 reduces mammalian ciliary motility.11
220211752012Loss of ASP but not ROPN1 reduces mammalian ciliary motility.11
207057942011Functional expression of ropporin in human testis and ejaculated spermatozoa.12
212402912011CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath.17
216545222011Cancer testis antigen, ropporin, is a potential target for multiple myeloma immunotherapy.11
207057942011Functional expression of ropporin in human testis and ejaculated spermatozoa.12
212402912011CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath.17
216545222011Cancer testis antigen, ropporin, is a potential target for multiple myeloma immunotherapy.11
201078402010Kalirin: a novel genetic risk factor for ischemic stroke.31

Citation

Dessen P

ROPN1 (rhophilin associated tail protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49887/gene-explorer/js/lib/gene-fusions/?id=49887