SYN3 (synapsin III)

2007-12-01  

Identity

HGNC
SYN3
LOCATION
22q12.3
LOCUSID
8224
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8224
MIM: 602705
HGNC: 11496
Ensembl: ENSG00000185666

Variants:

dbSNP: 8224
ClinVar: 8224
TCGA: ENSG00000185666
COSMIC: SYN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185666ENST00000332840A0A0A0MR68
ENSG00000185666ENST00000358763O14994
ENSG00000185666ENST00000358763A0A024R1I8
ENSG00000185666ENST00000412575Q4TT46
ENSG00000185666ENST00000441821A6ZJ82
ENSG00000185666ENST00000619146A0A087WTG8

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Serotonin Neurotransmitter Release CycleREACTOMER-HSA-181429
Dopamine Neurotransmitter Release CycleREACTOMER-HSA-212676

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371666142023Molecular and in silico analyses of SYN III gene variants in autism spectrum disorder.0
371666142023Molecular and in silico analyses of SYN III gene variants in autism spectrum disorder.0
350773252022Investigation of possible associations of the BDNF, SNAP-25 and SYN III genes with the neurocognitive measures: BDNF and SNAP-25 genes might be involved in attention domain, SYN III gene in executive function.1
350773252022Investigation of possible associations of the BDNF, SNAP-25 and SYN III genes with the neurocognitive measures: BDNF and SNAP-25 genes might be involved in attention domain, SYN III gene in executive function.1
293308842018Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains.20
293308842018Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains.20
268485872016Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells.8
275157002016DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression.11
268485872016Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells.8
275157002016DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression.11
259675502015α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.60
259675502015α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.60
245863012014No association of four candidate genetic variants in MnSOD and SYNIII with Parkinson's disease in two Chinese populations.2
245863012014No association of four candidate genetic variants in MnSOD and SYNIII with Parkinson's disease in two Chinese populations.2
237681042013Association of synapsin III gene with adult attention deficit hyperactivity disorder.6

Citation

Dessen P

SYN3 (synapsin III)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49902/case-report-explorer/gene-explorer/