TLE3 (TLE family member 3, transcriptional corepressor)

2008-03-01  

Identity

HGNC
TLE3
LOCATION
15q23
LOCUSID
7090
ALIAS
ESG,ESG3,GRG3,HsT18976
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7090
MIM: 600190
HGNC: 11839
Ensembl: ENSG00000140332

Variants:

dbSNP: 7090
ClinVar: 7090
TCGA: ENSG00000140332
COSMIC: TLE3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140332ENST00000317509Q04726
ENSG00000140332ENST00000440567Q04726
ENSG00000140332ENST00000451782Q04726
ENSG00000140332ENST00000537387Q672R2
ENSG00000140332ENST00000557907Q04726
ENSG00000140332ENST00000557919H0YKH0
ENSG00000140332ENST00000557984H0YKH5
ENSG00000140332ENST00000557997Q04726
ENSG00000140332ENST00000558201H0YKN8
ENSG00000140332ENST00000558379Q04726
ENSG00000140332ENST00000558939Q04726
ENSG00000140332ENST00000559048Q04726
ENSG00000140332ENST00000559191H0YNI7
ENSG00000140332ENST00000559929H0YL70
ENSG00000140332ENST00000560525H0YLI3
ENSG00000140332ENST00000560589H0YNT2
ENSG00000140332ENST00000560939H0YKT5
ENSG00000140332ENST00000561453H0YLW9
ENSG00000140332ENST00000627388A0A0D9SES8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381774112024The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.0
381774112024The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.0
373025182023HHEX suppresses advanced thyroid cancer by interacting with TLE3.3
373025182023HHEX suppresses advanced thyroid cancer by interacting with TLE3.3
335719072021Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.1
345513062021Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.9
335719072021Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.1
345513062021Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.9
318551782019TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth.18
318551782019TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth.18
293740672018RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.48
293740672018RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.48
281071932017MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling.27
286896572017Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.37
288596152017Identification of predictive markers of the therapeutic effect of eribulin chemotherapy for locally advanced or metastatic breast cancer.9

Citation

Dessen P

TLE3 (TLE family member 3, transcriptional corepressor)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50058/favicon/cancer-prone-explorer/