APOC1 (apolipoprotein C1)

2008-07-01  

Identity

HGNC
APOC1
LOCATION
19q13.32
LOCUSID
341
ALIAS
Apo-CI,ApoC-I,apo-CIB,apoC-IB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 341
MIM: 107710
HGNC: 607
Ensembl: ENSG00000130208

Variants:

dbSNP: 341
ClinVar: 341
TCGA: ENSG00000130208
COSMIC: APOC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130208ENST00000586638K7ELM9
ENSG00000130208ENST00000588750P02654
ENSG00000130208ENST00000588750A0A024R0T8
ENSG00000130208ENST00000588802P02654
ENSG00000130208ENST00000588802A0A024R0T8
ENSG00000130208ENST00000589078K7EKP1
ENSG00000130208ENST00000589781K7EPR9
ENSG00000130208ENST00000590334K7EJI9
ENSG00000130208ENST00000592176K7ELU7
ENSG00000130208ENST00000592535K7ERI9
ENSG00000130208ENST00000592885K7EPF9

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
VLDL interactionsREACTOMER-HSA-8855121
VLDL biosynthesisREACTOMER-HSA-8866423

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164742099MTTPGenePathwayassociated

References

Pubmed IDYearTitleCitations
373286022024Protective Association of APOC1/rs4420638 with Risk of Obesity: A case-control Study in Portuguese Children.0
385150732024APOC1 is a prognostic biomarker associated with M2 macrophages in ovarian cancer.0
373286022024Protective Association of APOC1/rs4420638 with Risk of Obesity: A case-control Study in Portuguese Children.0
385150732024APOC1 is a prognostic biomarker associated with M2 macrophages in ovarian cancer.0
363020882023ApoC1 promotes glioma metastasis by enhancing epithelial-mesenchymal transition and activating the STAT3 pathway.0
365639232023ZNF460 mediates epithelial-mesenchymal transition to promote gastric cancer progression by transactivating APOC1 expression.6
368910522023APOC1 as a novel diagnostic biomarker for DN based on machine learning algorithms and experiment.3
379818732023miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFβ2 signaling pathway.0
363020882023ApoC1 promotes glioma metastasis by enhancing epithelial-mesenchymal transition and activating the STAT3 pathway.0
365639232023ZNF460 mediates epithelial-mesenchymal transition to promote gastric cancer progression by transactivating APOC1 expression.6
368910522023APOC1 as a novel diagnostic biomarker for DN based on machine learning algorithms and experiment.3
379818732023miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFβ2 signaling pathway.0
339352852022Associations of genetic variants of lysophosphatidylcholine metabolic enzymes with levels of serum lipids.3
345967272022Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin.0
346253072022Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk.17

Citation

Dessen P

APOC1 (apolipoprotein C1)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50188/gene-fusions-explorer/favicon/gene-explorer/