PDS5A (PDS5 cohesin associated factor A)

2008-07-01  

Identity

HGNC
PDS5A
LOCATION
4p14
LOCUSID
23244
ALIAS
PIG54,SCC-112,SCC112
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23244
MIM: 613200
HGNC: 29088
Ensembl: ENSG00000121892

Variants:

dbSNP: 23244
ClinVar: 23244
TCGA: ENSG00000121892
COSMIC: PDS5A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121892ENST00000303538Q29RF7
ENSG00000121892ENST00000303538G1UI16
ENSG00000121892ENST00000503396Q29RF7
ENSG00000121892ENST00000507020H0Y9L6
ENSG00000121892ENST00000512643H0Y9X6
ENSG00000121892ENST00000513798H0Y9L9

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Establishment of Sister Chromatid CohesionREACTOMER-HSA-2468052
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884
Cohesin Loading onto ChromatinREACTOMER-HSA-2470946

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
355064372022Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.3
357108362022The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism.12
355064372022Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.3
357108362022The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism.12
340708272021PDS5A and PDS5B in Cohesin Function and Human Disease.19
340708272021PDS5A and PDS5B in Cohesin Function and Human Disease.19
317578072020PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.28
317578072020PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.28
299171102019Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing.29
299171102019Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing.29
292175912017Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.349
292175912017Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.349
275493712016Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications.6
275493712016Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications.6
260518942015Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2.42

Citation

Dessen P

PDS5A (PDS5 cohesin associated factor A)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50272/img/img/gene-fusions/?id=50272