LARS1 (leucyl-tRNA synthetase 1)

2008-09-01  

Identity

HGNC
LARS1
LOCATION
5q32
LOCUSID
51520
ALIAS
HSPC192,ILFS1,LARS,LEURS,LEUS,LFIS,LRS,PIG44,RNTLS,hr025Cl

Other Information

Locus ID:

NCBI: 51520
MIM: 151350
HGNC: 6512
Ensembl: ENSG00000133706

Variants:

dbSNP: 51520
ClinVar: 51520
TCGA: ENSG00000133706
COSMIC: LARS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133706ENST00000274562Q9P2J5
ENSG00000133706ENST00000394434Q9P2J5
ENSG00000133706ENST00000510191Q9P2J5
ENSG00000133706ENST00000674447B4DER1

Pathways

PathwaySourceExternal ID
Aminoacyl-tRNA biosynthesisKEGGko00970
Aminoacyl-tRNA biosynthesisKEGGhsa00970
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGhsa_M00359
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGM00359
Gene ExpressionREACTOMER-HSA-74160
tRNA AminoacylationREACTOMER-HSA-379724
Cytosolic tRNA aminoacylationREACTOMER-HSA-379716
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
SeMet incorporation into proteinsREACTOMER-HSA-2408517

References

Pubmed IDYearTitleCitations
356140562022O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.7
359624512022Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification.6
356140562022O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.7
359624512022Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification.6
333006502021Severe course with lethal hepatocellular injury and skeletal muscular dysgenesis in a neonate with infantile liver failure syndrome type 1 caused by novel LARS1 mutations.6
333140432021Infantile Liver Failure Syndrome 1 associated with a novel variant of the LARS1 gene: Clinical, genetic, and functional characterization.1
343251322021Leucyl-tRNA synthetase 1 is required for proliferation of TSC-null cells.1
333006502021Severe course with lethal hepatocellular injury and skeletal muscular dysgenesis in a neonate with infantile liver failure syndrome type 1 caused by novel LARS1 mutations.6
333140432021Infantile Liver Failure Syndrome 1 associated with a novel variant of the LARS1 gene: Clinical, genetic, and functional characterization.1
343251322021Leucyl-tRNA synthetase 1 is required for proliferation of TSC-null cells.1
317806252020Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1.35
322323612020Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.10
326993522020Genotypic diversity and phenotypic spectrum of infantile liver failure syndrome type 1 due to variants in LARS1.9
317806252020Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1.35
322323612020Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.10

Citation

Dessen P

LARS1 (leucyl-tRNA synthetase 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50329/img/gene-explorer/case-report-explorer/