DHRS3 (dehydrogenase/reductase 3)

2008-09-01  

Identity

HGNC
DHRS3
LOCATION
1p36.21
LOCUSID
9249
ALIAS
DD83.1,RDH17,Rsdr1,SDR1,SDR16C1,retSDR1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9249
MIM: 612830
HGNC: 17693
Ensembl: ENSG00000162496

Variants:

dbSNP: 9249
ClinVar: 9249
TCGA: ENSG00000162496
COSMIC: DHRS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162496ENST00000430996Q5SUY4
ENSG00000162496ENST00000464917A0A087WTY3
ENSG00000162496ENST00000616661O75911

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The retinoid cycle in cones (daylight vision)REACTOMER-HSA-2187335
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368409462023CircDHRS3 inhibits prostate cancer cell proliferation and metastasis through the circDHRS3/miR-421/MEIS2 axis.3
368409462023CircDHRS3 inhibits prostate cancer cell proliferation and metastasis through the circDHRS3/miR-421/MEIS2 axis.3
339026582021Inhibition of retinoic acid receptor α phosphorylation represses the progression of triple-negative breast cancer via transactivating miR-3074-5p to target DHRS3.7
339026582021Inhibition of retinoic acid receptor α phosphorylation represses the progression of triple-negative breast cancer via transactivating miR-3074-5p to target DHRS3.7
294470062018Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.20
296891922018Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development.92
294470062018Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.20
296891922018Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development.92
282324912017The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasis.17
283714102017New genes associated with rheumatoid arthritis identified by gene expression profiling.9
282324912017The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasis.17
283714102017New genes associated with rheumatoid arthritis identified by gene expression profiling.9
247333972014The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis.63
247333972014The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis.63
240059082013The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development.75

Citation

Dessen P

DHRS3 (dehydrogenase/reductase 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50385/tumors-explorer/