MPRIP (myosin phosphatase Rho interacting protein)

2008-10-01 Affiliation

Identity

HGNC

MPRIP

LOCATION

17p11.2

LOCUSID

23164

ALIAS

M-RIP,MRIP,RHOIP3,RIP3,p116Rip

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23164
MIM: 612935
HGNC: 30321
Ensembl: ENSG00000133030

Variants:

dbSNP: 23164
ClinVar: 23164
TCGA: ENSG00000133030
COSMIC: MPRIP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000133030	ENST00000313485	H0Y2S9
ENSG00000133030	ENST00000341712	Q6WCQ1
ENSG00000133030	ENST00000395806	A8MZF8
ENSG00000133030	ENST00000395811	Q6WCQ1
ENSG00000133030	ENST00000414263	H0Y7E2
ENSG00000133030	ENST00000429184	H7C3G6
ENSG00000133030	ENST00000462033	K7EL39
ENSG00000133030	ENST00000466186	A0A1W2PPU9
ENSG00000133030	ENST00000577514	J3KSK7
ENSG00000133030	ENST00000578209	J3QRL2
ENSG00000133030	ENST00000579361	J3QL44
ENSG00000133030	ENST00000579832	K7EJ14
ENSG00000133030	ENST00000584067	J3KSW8
ENSG00000133030	ENST00000651222	A0A494BZV2

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Oncogenic MAPK signaling	REACTOME	R-HSA-6802957
Signaling by BRAF and RAF fusions	REACTOME	R-HSA-6802952

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38494770	2024	[circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation and apoptosis of non-small cell lung cancer cells].	0
38494770	2024	[circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation and apoptosis of non-small cell lung cancer cells].	0
36979361	2023	PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription.	4
36979361	2023	PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription.	4
33918018	2021	The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus.	10
33918018	2021	The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus.	10
24901049	2014	The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.	115
24901049	2014	The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.	115
22349701	2012	Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions.	18
22349701	2012	Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions.	18
21242312	2011	An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.	24
21242312	2011	An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.	24
18636174	2008	M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.	7
18636174	2008	M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.	7
15545284	2005	p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA.	33

Citation

Dessen P

MPRIP (myosin phosphatase Rho interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50434/deep-insight-explorer/gene-fusions-explorer/