LRPAP1 (LDL receptor related protein associated protein 1)

2008-12-01  

Identity

HGNC
LRPAP1
LOCATION
4p16.3
LOCUSID
4043
ALIAS
A2MRAP,A2RAP,HBP44,MRAP,MYP23,RAP,alpha-2-MRAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4043
MIM: 104225
HGNC: 6701
Ensembl: ENSG00000163956

Variants:

dbSNP: 4043
ClinVar: 4043
TCGA: ENSG00000163956
COSMIC: LRPAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163956ENST00000515119D6REW6
ENSG00000163956ENST00000648517A0A3B3IRQ7
ENSG00000163956ENST00000650182P30533

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368485312023Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated and Clathrin Independent Endocytosis, Ameliorating Renal Aminoglycoside Nephrotoxicity.6
380351032023LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation.0
368485312023Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated and Clathrin Independent Endocytosis, Ameliorating Renal Aminoglycoside Nephrotoxicity.6
380351032023LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation.0
349365472022The relationship of ADAMTSL2 and LRPAP1 gene methylation level with rheumatoid arthritis activity.1
349365472022The relationship of ADAMTSL2 and LRPAP1 gene methylation level with rheumatoid arthritis activity.1
340581952021Molecular chaperone RAP interacts with LRP1 in a dynamic bivalent mode and enhances folding of ligand-binding regions of other LDLR family receptors.3
344727632021Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry.4
340581952021Molecular chaperone RAP interacts with LRP1 in a dynamic bivalent mode and enhances folding of ligand-binding regions of other LDLR family receptors.3
344727632021Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry.4
316075222020Rhegmatogenous Retinal Detachment in Nonsyndromic High Myopia Associated with Recessive Mutations in LRPAP1.2
316075222020Rhegmatogenous Retinal Detachment in Nonsyndromic High Myopia Associated with Recessive Mutations in LRPAP1.2
299551302019LRPAP1 is a frequent proliferation-inducing antigen of BCRs of mantle cell lymphomas and can be used for specific therapeutic targeting.18
299551302019LRPAP1 is a frequent proliferation-inducing antigen of BCRs of mantle cell lymphomas and can be used for specific therapeutic targeting.18
262718382016Clinical Characterization of LRPAP1-Related Pediatric High Myopia.7

Citation

Dessen P

LRPAP1 (LDL receptor related protein associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50604/gene-explorer/case-report-explorer/deep-insight-explorer/