BHLHE41 (basic helix-loop-helix family member e41)

2009-01-01  

Identity

HGNC
BHLHE41
LOCATION
12p12.1
LOCUSID
79365
ALIAS
BHLHB3,DEC2,FNSS1,SHARP1,hDEC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79365
MIM: 606200
HGNC: 16617
Ensembl: ENSG00000123095

Variants:

dbSNP: 79365
ClinVar: 79365
TCGA: ENSG00000123095
COSMIC: BHLHE41

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123095ENST00000242728Q9C0J9
ENSG00000123095ENST00000242728A0A024RAV8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

References

Pubmed IDYearTitleCitations
375114892023Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development.2
375114892023Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development.2
339902152021Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma.4
346386902021The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation.7
347689592021BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma.4
339902152021Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma.4
346386902021The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation.7
347689592021BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma.4
320732382020BHLHE41 suppresses MCF-7 cell invasion via MAPK/JNK pathway.7
325219002020MicroRNA-301a inhibits the progression of osteosarcoma by regulating DEC2.1
328581022020ARID1A-dependent permissive chromatin accessibility licenses estrogen-receptor signaling to regulate circadian rhythms genes in endometrial cancer.5
331015422020DEC2 Serves as Potential Tumor Suppressor in Breast Carcinoma.3
331761512020TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41.23
320732382020BHLHE41 suppresses MCF-7 cell invasion via MAPK/JNK pathway.7
325219002020MicroRNA-301a inhibits the progression of osteosarcoma by regulating DEC2.1

Citation

Dessen P

BHLHE41 (basic helix-loop-helix family member e41)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50651/haematological-explorer/js/lib/case-report-explorer/