MAG (myelin associated glycoprotein)

2009-01-01  

Identity

HGNC
MAG
LOCATION
19q13.12
LOCUSID
4099
ALIAS
GMA,S-MAG,SIGLEC-4A,SIGLEC4A,SPG75
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4099
MIM: 159460
HGNC: 6783
Ensembl: ENSG00000105695

Variants:

dbSNP: 4099
ClinVar: 4099
TCGA: ENSG00000105695
COSMIC: MAG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105695ENST00000361922P20916
ENSG00000105695ENST00000392213P20916
ENSG00000105695ENST00000537831P20916
ENSG00000105695ENST00000595791M0R3B9
ENSG00000105695ENST00000597035M0R3I4
ENSG00000105695ENST00000600291M0QZU4

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
p75NTR regulates axonogenesisREACTOMER-HSA-193697
Axonal growth inhibition (RHOA activation)REACTOMER-HSA-193634

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
346019912021Myelin-associated proteins are potential diagnostic markers in patients with primary brain tumour.0
346019912021Myelin-associated proteins are potential diagnostic markers in patients with primary brain tumour.0
326293242020Recessive null-allele variants in MAG associated with spastic ataxia, nystagmus, neuropathy, and dystonia.0
326293242020Recessive null-allele variants in MAG associated with spastic ataxia, nystagmus, neuropathy, and dystonia.0
309925312019Clinical and laboratory features of anti-MAG neuropathy without monoclonal gammopathy.7
309925312019Clinical and laboratory features of anti-MAG neuropathy without monoclonal gammopathy.7
294775852018Association between abnormal serum myelin-specific protein levels and white matter integrity in first-episode and drug-naïve patients with major depressive disorder.5
294775852018Association between abnormal serum myelin-specific protein levels and white matter integrity in first-episode and drug-naïve patients with major depressive disorder.5
260650012015Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies.18
261799192015Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.25
260650012015Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies.18
261799192015Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.25
229406292013An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease.16
237267662013The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children.19
241295692013LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.58

Citation

Dessen P

MAG (myelin associated glycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50654/css/js/haematological-explorer/