RDX (radixin)

2009-03-01  

Identity

HGNC
RDX
LOCATION
11q22.3
LOCUSID
5962
ALIAS
DFNB24
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5962
MIM: 179410
HGNC: 9944
Ensembl: ENSG00000137710

Variants:

dbSNP: 5962
ClinVar: 5962
TCGA: ENSG00000137710
COSMIC: RDX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137710ENST00000528498P35241
ENSG00000137710ENST00000528556E9PN07
ENSG00000137710ENST00000528900P35241
ENSG00000137710ENST00000530131E9PNP4
ENSG00000137710ENST00000530301P35241
ENSG00000137710ENST00000530749P35241
ENSG00000137710ENST00000532118E9PNV3
ENSG00000137710ENST00000533678E9PRS5
ENSG00000137710ENST00000533991E9PQ82
ENSG00000137710ENST00000534683E9PKN5
ENSG00000137710ENST00000544551P35241
ENSG00000137710ENST00000642511A0A2R8Y5P0
ENSG00000137710ENST00000645312A0A2R8Y4H6
ENSG00000137710ENST00000645495P35241
ENSG00000137710ENST00000645495B0YJ88
ENSG00000137710ENST00000645527A0A2R8Y7M3
ENSG00000137710ENST00000646663A0A2R8Y5S7
ENSG00000137710ENST00000647231P35241

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Regulation of actin cytoskeletonKEGGko04810
Tight junctionKEGGhsa04530
Regulation of actin cytoskeletonKEGGhsa04810
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Recycling pathway of L1REACTOMER-HSA-437239

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
318431952020Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM.2
320983342020ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion.31
321605482020ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.40
327745162020Radixin Relocalization and Nonmuscle α-Actinin Expression Are Features of Remodeling Cardiomyocytes in Adult Patients with Dilated Cardiomyopathy.9
333617752020Radixin modulates the function of outer hair cell stereocilia.5
318431952020Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM.2
320983342020ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion.31
321605482020ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.40
327745162020Radixin Relocalization and Nonmuscle α-Actinin Expression Are Features of Remodeling Cardiomyocytes in Adult Patients with Dilated Cardiomyopathy.9
333617752020Radixin modulates the function of outer hair cell stereocilia.5
310185752019Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition.37
312505712019Identification of novel variants in MYO15A, OTOF, and RDX with hearing loss by next-generation sequencing.10
313823742019Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology.23
310185752019Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition.37
312505712019Identification of novel variants in MYO15A, OTOF, and RDX with hearing loss by next-generation sequencing.10

Citation

Dessen P

RDX (radixin)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50787/js/lib/case-report-explorer/