TOM1L1 (target of myb1 like 1 membrane trafficking protein)

2009-05-01  

Identity

HGNC
TOM1L1
LOCATION
17q22
LOCUSID
10040
ALIAS
SRCASM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10040
MIM: 604701
HGNC: 11983
Ensembl: ENSG00000141198

Variants:

dbSNP: 10040
ClinVar: 10040
TCGA: ENSG00000141198
COSMIC: TOM1L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141198ENST00000348161O75674
ENSG00000141198ENST00000445275J3KQU4
ENSG00000141198ENST00000536554O75674
ENSG00000141198ENST00000570371O75674
ENSG00000141198ENST00000570499I3L4G0
ENSG00000141198ENST00000570965I3L1T2
ENSG00000141198ENST00000571319I3L0N2
ENSG00000141198ENST00000572158I3L4I4
ENSG00000141198ENST00000572298I3L1Q1
ENSG00000141198ENST00000572360I3L3M3
ENSG00000141198ENST00000572405I3L3T4
ENSG00000141198ENST00000572576I3L1G1
ENSG00000141198ENST00000573607I3L4N3
ENSG00000141198ENST00000574318K7EP47
ENSG00000141198ENST00000575333O75674
ENSG00000141198ENST00000575882O75674
ENSG00000141198ENST00000575909I3L367
ENSG00000141198ENST00000576932I3NI44

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352388642022Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling.8
352388642022Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling.8
268994822016TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion.22
268994822016TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion.22
230233242012Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts.10
230233242012Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts.10
209441342010Decreased Srcasm expression in esophageal squamous cell carcinoma in a Chinese population.1
209441342010Decreased Srcasm expression in esophageal squamous cell carcinoma in a Chinese population.1
192206272009Decreased Srcasm expression in hyperproliferative cutaneous lesions.3
197980562009Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor.17
201826322009TOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation.1
192206272009Decreased Srcasm expression in hyperproliferative cutaneous lesions.3
197980562009Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor.17
201826322009TOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation.1
183678162008Recruitment of Tom1L1/Srcasm to endosomes and the midbody by Tsg101.12

Citation

Dessen P

TOM1L1 (target of myb1 like 1 membrane trafficking protein)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50873/favicon/gene-explorer/