NFIX (nuclear factor I X)

2009-05-01 Affiliation

Identity

HGNC

NFIX

LOCATION

19p13.13

LOCUSID

4784

ALIAS

CTF,MRSHSS,NF-I/X,NF1-X,NF1A,SOTOS2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4784
MIM: 164005
HGNC: 7788
Ensembl: ENSG00000008441

Variants:

dbSNP: 4784
ClinVar: 4784
TCGA: ENSG00000008441
COSMIC: NFIX

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000008441	ENST00000358552	C9JWJ8
ENSG00000008441	ENST00000360105	C9JWJ8
ENSG00000008441	ENST00000397661	Q14938
ENSG00000008441	ENST00000585382	K7EMQ5
ENSG00000008441	ENST00000585575	Q14938
ENSG00000008441	ENST00000585575	D2DXM9
ENSG00000008441	ENST00000586797	K7EPU2
ENSG00000008441	ENST00000586873	K7ESG9
ENSG00000008441	ENST00000587260	Q14938
ENSG00000008441	ENST00000587760	Q14938
ENSG00000008441	ENST00000588228	K7EN08
ENSG00000008441	ENST00000590027	K7EKH0
ENSG00000008441	ENST00000591028	K7EJB0
ENSG00000008441	ENST00000592199	Q14938

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	REACTOME	R-HSA-504046
RNA Polymerase III Transcription	REACTOME	R-HSA-74158
RNA Polymerase III Abortive And Retractive Initiation	REACTOME	R-HSA-749476
RNA Polymerase III Transcription Termination	REACTOME	R-HSA-73980

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36469009	2023	A Novel Tumor-Promoting Role for Nuclear Factor IX in Glioblastoma Is Mediated through Transcriptional Activation of GINS1.	6
36495291	2023	CircNFIX stimulates the proliferation, invasion, and stemness properties of ovarian cancer cells by enhancing SH3RF3 mRNA stability via binding LIN28B.	2
36901722	2023	NFIXing Cancer: The Role of NFIX in Oxidative Stress Response and Cell Fate.	2
37336770	2023	A rare cause of intellectual disability: Novel mutations of NFIX gene in two patients with clinical features of Marshall-Smith syndrome and Malan syndrome.	0
37713785	2023	m6A-modified circNFIX promotes ovarian cancer progression and immune escape via activating IL-6R/JAK1/STAT3 signaling by sponging miR-647.	4
36469009	2023	A Novel Tumor-Promoting Role for Nuclear Factor IX in Glioblastoma Is Mediated through Transcriptional Activation of GINS1.	6
36495291	2023	CircNFIX stimulates the proliferation, invasion, and stemness properties of ovarian cancer cells by enhancing SH3RF3 mRNA stability via binding LIN28B.	2
36901722	2023	NFIXing Cancer: The Role of NFIX in Oxidative Stress Response and Cell Fate.	2
37336770	2023	A rare cause of intellectual disability: Novel mutations of NFIX gene in two patients with clinical features of Marshall-Smith syndrome and Malan syndrome.	0
37713785	2023	m6A-modified circNFIX promotes ovarian cancer progression and immune escape via activating IL-6R/JAK1/STAT3 signaling by sponging miR-647.	4
35791460	2022	CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis.	5
35791460	2022	CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis.	5
34132359	2021	Long non‑coding RNA SNHG3 promotes the development of non‑small cell lung cancer via the miR‑1343‑3p/NFIX pathway.	11
34492536	2021	A novel miRNA-762/NFIX pathway modulates LPS-induced acute lung injury.	2
34132359	2021	Long non‑coding RNA SNHG3 promotes the development of non‑small cell lung cancer via the miR‑1343‑3p/NFIX pathway.	11

Citation

Dessen P

NFIX (nuclear factor I X)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50885/gene-fusions-explorer/js/lib/gene-explorer/