RXFP1 (relaxin family peptide receptor 1)

2009-05-01  

Identity

HGNC
RXFP1
LOCATION
4q32.1
LOCUSID
59350
ALIAS
LGR7,RXFPR1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 59350
MIM: 606654
HGNC: 19718
Ensembl: ENSG00000171509

Variants:

dbSNP: 59350
ClinVar: 59350
TCGA: ENSG00000171509
COSMIC: RXFP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171509ENST00000307765Q9HBX9
ENSG00000171509ENST00000342048E9PIF0
ENSG00000171509ENST00000343542Q9HBX9
ENSG00000171509ENST00000423548B4DGP2
ENSG00000171509ENST00000448688A0A0A0MT52
ENSG00000171509ENST00000460056E9PCA3
ENSG00000171509ENST00000470033Q9HBX9
ENSG00000171509ENST00000471616Q9HBX9
ENSG00000171509ENST00000613319A0A087WWV0

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Relaxin receptorsREACTOMER-HSA-444821
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364433812022Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.4
364433812022Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.4
344549452021Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2.6
349721062021Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1.1
344549452021Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2.6
349721062021Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1.1
322976702020The anti-fibrotic actions of relaxin are mediated through AT(2) R-associated protein phosphatases via RXFP1-AT(2) R functional crosstalk in human cardiac myofibroblasts.8
322976702020The anti-fibrotic actions of relaxin are mediated through AT(2) R-associated protein phosphatases via RXFP1-AT(2) R functional crosstalk in human cardiac myofibroblasts.8
307099042019MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis.23
314191612019Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis.10
307099042019MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis.23
314191612019Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis.10
267614402016Endometrial LGR7 expression and implantation failure.1
270885792016The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1.20
273106522016Expression of RXFP1 Is Decreased in Idiopathic Pulmonary Fibrosis. Implications for Relaxin-based Therapies.36

Citation

Dessen P

RXFP1 (relaxin family peptide receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50924/gene-fusions/js/lib/case-report-explorer/