PPME1 (protein phosphatase methylesterase 1)

2009-06-01  

Identity

HGNC
PPME1
LOCATION
11q13.4
LOCUSID
51400
ALIAS
ABDH19,PME-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51400
MIM: 611117
HGNC: 30178
Ensembl: ENSG00000214517

Variants:

dbSNP: 51400
ClinVar: 51400
TCGA: ENSG00000214517
COSMIC: PPME1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000214517ENST00000328257Q9Y570
ENSG00000214517ENST00000328257A0A140VK39
ENSG00000214517ENST00000398427Q9Y570

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385888042024The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.0
385888042024The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.0
364619112023PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers.4
364619112023PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers.4
320710792020Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1.34
323512912020DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p.13
320710792020Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1.34
323512912020DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p.13
317148942019Glycogen synthase kinase-3β suppresses the expression of protein phosphatase methylesterase-1 through β-catenin.3
317148942019Glycogen synthase kinase-3β suppresses the expression of protein phosphatase methylesterase-1 through β-catenin.3
295772692018PME-1 is regulated by USP36 in ERK and Akt signaling pathways.6
303400292018Hydrogen peroxide redistributes the localization of protein phosphatase methylesterase 1.2
295772692018PME-1 is regulated by USP36 in ERK and Akt signaling pathways.6
303400292018Hydrogen peroxide redistributes the localization of protein phosphatase methylesterase 1.2
278109032017NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability.41

Citation

Dessen P

PPME1 (protein phosphatase methylesterase 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50942/case-report-explorer/haematological-explorer/