CADM3 (cell adhesion molecule 3)

2009-08-01  

Identity

HGNC
CADM3
LOCATION
1q23.2
LOCUSID
57863
ALIAS
BIgR,IGSF4B,NECL1,Necl-1,TSLL1,synCAM3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57863
MIM: 609743
HGNC: 17601
Ensembl: ENSG00000162706

Variants:

dbSNP: 57863
ClinVar: 57863
TCGA: ENSG00000162706
COSMIC: CADM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162706ENST00000368124Q8N126
ENSG00000162706ENST00000368125Q8N126
ENSG00000162706ENST00000416746A0A0C4DG09

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Nectin/Necl trans heterodimerizationREACTOMER-HSA-420597

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385150572024Clinical significance of low expression of CADM3 in breast cancer and preliminary exploration of related mechanisms.0
385150572024Clinical significance of low expression of CADM3 in breast cancer and preliminary exploration of related mechanisms.0
338899412021A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement.4
338899412021A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement.4
298087992018miR-140-5p suppresses retinoblastoma cell proliferation, migration, and invasion by targeting CEMIP and CADM3.14
298087992018miR-140-5p suppresses retinoblastoma cell proliferation, migration, and invasion by targeting CEMIP and CADM3.14
241122382013Nectin and junctional adhesion molecule are critical cell adhesion molecules for the apico-basal alignment of adherens and tight junctions in epithelial cells.8
241122382013Nectin and junctional adhesion molecule are critical cell adhesion molecules for the apico-basal alignment of adherens and tight junctions in epithelial cells.8
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.24
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.24
213252822011Crystal Structure of the cis-Dimer of Nectin-1: implications for the architecture of cell-cell junctions.28
213252822011Crystal Structure of the cis-Dimer of Nectin-1: implications for the architecture of cell-cell junctions.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
205982322010Nectin-like molecule 1 inhibits the migration and invasion of U251 glioma cells by regulating the expression of an extracellular matrix protein osteopontin.4
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37

Citation

Dessen P

CADM3 (cell adhesion molecule 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51045/favicon/case-report-explorer/