WIPF1 (WAS/WASL interacting protein family member 1)

2009-09-01  

Identity

HGNC
WIPF1
LOCATION
2q31.1
LOCUSID
7456
ALIAS
PRPL-2,WAS2,WASPIP,WIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7456
MIM: 602357
HGNC: 12736
Ensembl: ENSG00000115935

Variants:

dbSNP: 7456
ClinVar: 7456
TCGA: ENSG00000115935
COSMIC: WIPF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115935ENST00000272746O43516
ENSG00000115935ENST00000359761O43516
ENSG00000115935ENST00000359761A0A140VJZ9
ENSG00000115935ENST00000392546O43516
ENSG00000115935ENST00000392546A0A140VJZ9
ENSG00000115935ENST00000392547O43516
ENSG00000115935ENST00000392547A0A140VJZ9
ENSG00000115935ENST00000409415E9PB87
ENSG00000115935ENST00000409891O43516
ENSG00000115935ENST00000410117B8ZZ90
ENSG00000115935ENST00000436221C9JTB9
ENSG00000115935ENST00000455428C9JB04

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
291729472020Crosstalk between WIP and Rho family GTPases.4
321477262020DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons.19
326320982020PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer.72
327081832020The Disordered Cellular Multi-Tasker WIP and Its Protein-Protein Interactions: A Structural View.5
291729472020Crosstalk between WIP and Rho family GTPases.4
321477262020DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons.19
326320982020PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer.72
327081832020The Disordered Cellular Multi-Tasker WIP and Its Protein-Protein Interactions: A Structural View.5
292152672018New Structural Insights into Formation of the Key Actin Regulating WIP-WASp Complex Determined by NMR and Molecular Imaging.4
300416602018WIPF1 antagonizes the tumor suppressive effect of miR-141/200c and is associated with poor survival in patients with PDAC.18
292152672018New Structural Insights into Formation of the Key Actin Regulating WIP-WASp Complex Determined by NMR and Molecular Imaging.4
300416602018WIPF1 antagonizes the tumor suppressive effect of miR-141/200c and is associated with poor survival in patients with PDAC.18
277423952017Hematopoietic stem cell transplantation corrects WIP deficiency.9
278634292017Epigenetically upregulated WIPF1 plays a major role in BRAF V600E-promoted papillary thyroid cancer aggressiveness.9
279398842017WIP promotes in-vitro invasion ability, anchorage independent growth and EMT progression of A549 lung adenocarcinoma cells by regulating RhoA levels.16

Citation

Dessen P

WIPF1 (WAS/WASL interacting protein family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51113/tumors-explorer/gene-fusions/?id=51113